摘要
目的:探讨宣肺逐饮汤加减对结核性胸膜炎患者血清C反应蛋白(CRP)、红细胞沉降率(ESR)、CD4+与CD4+/CD8+水平及临床疗效的影响。方法:125例结核性胸膜炎患者按照随机数字表法分为观察组65例和对照组60例,对照组采用抗结核药物联合胸腔穿刺抽液常规治疗;观察组在对照组基础上给予宣肺逐饮汤加减治疗。记录两组患者治疗前后中医证候积分、胸膜厚度以及炎症因子(CRP、ESR)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、CD4+、CD4+/CD8+水平变化及治疗后不良反应的发生情况,并进行临床疗效比较。结果:治疗后两组患者中医证候积分较治疗前均明显下降(P<0.05),且观察组较对照组下降明显(P<0.05);观察组临床总有效率92.31%,显著优于对照组的70.00%(P<0.05);治疗后两组患者CRP、ESR水平及胸膜厚度均较治疗前下降(P<0.05),且观察组低于对照组(P<0.05);治疗后两组患者IgA、IgG、IgM、CD4+、CD4+/CD8+水平较治疗前均显著升高(P<0.05),且观察组患者水平高于对照组(P<0.05);观察组与对照组均无严重不良反应发生。结论:宣肺逐饮汤加减治疗能减轻结核性胸膜炎患者炎症反应,同时改善机体免疫功能,临床疗效好,安全性高。
Objective:To explore the effect of modified Xuanfei Zhuyin Decoction(宣肺逐饮汤)on serum C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)and CD4+,CD4+/CD8+levels in patients with tuberculous pleurisy.Methods:A total of 125 patients with tuberculous pleurisy were divided into the observation group(65 cases)and the control group(60 cases)according to the random number table method.The control group was treated with anti-tuberculosis drugs plus thoracic drainage and thoracentesis,and the observation group was given Modified Xuanfei Zhuyin Decoction on the basis of treatment of the control group.The scores of traditional Chinese medicine(TCM)syndromes,the pleural thickness and inflammatory factor levels(CRP,ESR)and immune function(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),CD4+,CD4+/CD8+levels before and after treatment and adverse reactions after treatment were recorded between the two groups.And the clinical efficacy was compared.Results:After treatment,the TCM syndrome scores of the two groups of patients were significantly lower than those before treatment(P<0.05),and the TCM syndrome scores of the observation group were lower than those of the control group(P<0.05).The total clinical effective rate of 92.31%in the observation group was significantly better than the total clinical effective rate of 70.00%in the control group(P<0.05).After treatment,the pleural thickness,CRP and ESR levels of the two groups were lower than those before treatment(P<0.05).Pleural thickness,CRP and ESR levels of the observation group were lower than those of the control group after treatment(P<0.05).After treatment,the levels of IgA,IgG,IgM,CD4+,CD4+/CD8+in the two groups were significantly higher than those before treatment(P<0.05),and the observation group was higher than the control group(P<0.05).There were no serious adverse reactions in the two groups of patients.Conclusions:Modified Xuanfei Zhuyin Decoction can alleviate the inflammatory response in patients with tuberculous pleurisy,and improve the immune
作者
汪晓宇
李庆涛
李站领
张继东
李艳静
李颖
WANG Xiaoyu;LI Qingtao;LI Zhanling;ZHANG Jidong;LI Yanjing;LI Ying(Department of Respiratory Medicine,Qinhuangdao Third Hospital,Qinhuangdao 066000,China)
出处
《山东中医杂志》
2021年第9期948-951,988,共5页
Shandong Journal of Traditional Chinese Medicine
基金
秦皇岛市重点研发计划科技支撑项目(编号:201703A093)。
关键词
结核性胸膜炎
宣肺逐饮汤
C反应蛋白
红细胞降沉率
胸膜厚度
炎症反应
tuberculous pleurisy
Xuanfei Zhuyin Decoction
C-reactive protein
erythrocyte sedimentation rate
pleural thickness
inflammatory response
