摘要
目的了解中国孕产妇人群在孕产期的抑郁发生及变化情况,为中国孕产妇抑郁的相关研究提供数据支持和参考依据。方法 2015年8月至2016年10月选择山西省妇幼保健院、吉林省妇幼保健院、广东省珠海市妇幼保健院、广东省深圳市妇幼保健院、北京市海淀区妇幼保健院五个省市的妇幼保健院为研究现场,共招募1 284名孕产妇入组。使用爱丁堡产后抑郁量表(EPDS)对孕产妇孕13周(G13)、孕17周(G17)、孕24周(G24)、孕31周(G31)、孕37周(G37)、产后3天(D3)和产后42天(D42)7个时点的抑郁情况开展了前瞻性随访研究,以了解其在孕期不同阶段的抑郁状况及变化规律。结果孕产期在G13、G17、G24、G31、G37、D3和D42各个时点的可疑抑郁或抑郁的总体阳性率(>9分)分别为27.57%、21.46%、21.50%、20.84%、20.17%、22.20%、20.74%,其中孕早期检出率最高,整体呈下降趋势(D3略有升高),趋势性检验差异有统计学意义(χ^(2)=43.848,P<0.05);情感缺失分量表、焦虑分量表、抑郁分量表在孕13周的平均得分均高于其他时期,总体趋势在7个时点差异无统计学意义(P>0.05);各分量表不同时期的得分情况与EPDS总评分均有强相关性(r值分别为0.638、0.851、0.811,P<0.01);本研究中孕13周的自伤风险最高(4.83%),其余6个时点的阳性率分别为3.02%、2.24%、2.34%、2.89%、3.04%、2.47%。结论孕产妇在7个不同的孕产期时点抑郁检出率互不相同,总体呈下降趋势,应该从孕早期开始,提高对孕产妇整个孕产期的心理健康的关注,及时干预,以期改善孕产妇的心理健康与母婴结局。
Objective To understand occurrence and changes of depression in Chinese pregnant and lying-in women, and to provide data support and reference for related research on maternal depression in China.Methods From August 2015 to October 2016,1 284 pregnant women and puerperae were recruited from Shanxi Provincial Maternal and Child Health Hospital, Jilin Provincial Maternal and Child Health Hospital, Zhuhai Municipal Maternal and Child Health Hospital of Guangdong Province, Shenzhen Maternal and Child Health Hospital of Guangdong Province, and Haidian District Maternal and Child Health Hospital of Beijing.Edinburgh Postnatal Depression Scale(EPDS) was used to conduct a prospective follow up study on depression of the pregnant women and puerperae at 7 time points during pregnancy and postpartum: 13 weeks(G13),17 weeks(G17),24 weeks(G24),31 weeks(G31) and 37 weeks(G37) of gestation and 3 days after delivery(D3) and 42 days after delivery(D42) to investigate depression status and its change pattern in different stages of pregnancy and postpartum.Results The overall positive rate of suspected depression or depression(>9 scores) at 7 time points in pregnancy and postpartum(G13,G17,G24,G31,37,D3 and D42)were 27.57%,21.46%,21.50%,20.84%,20.17%,22.20% and 20.74% respectively, of which the detection rate of suspected depression or depression in early pregnancy was the highest and showed a decreasing trend(slightly increased at D3) on the whole, and the difference was statistically significant by trend test(χ^(2)=43.848,P<0.05).The average scores of the pregnant women and puerperae in affective deficit subscale, anxiety subscale and depression subscale at 13 weeks of pregnancy were all higher than those at other stages, while there was no statistically significant difference in the overall trend of the average scores among the 7 time points(P>0.05).There were strong correlations between the scores in the three subscales at different stages and the total EPDS score(r=0.638,0.851 and 0.811 respectively, all P<0.01).In this study
作者
杨业环
孙梦云
黄星
杨丽
郑睿敏
YANG Yehuan;SUN Mengyun;HUANG Xing;YANG Li;ZHENG Ruimin(National Center for Women and Children′s Health,China CDC,Beijing 100081,China)
出处
《中国妇幼健康研究》
2021年第8期1118-1122,共5页
Chinese Journal of Woman and Child Health Research
基金
中国疾控中心妇幼中心公共卫生突发应急反应机制运行项目(2015FY002)。
关键词
孕产期抑郁
队列研究
抑郁检出阳性率
爱丁堡产后抑郁量表
depression during pregnancy and postpartum
cohort study
positive detective rate of depression
Edinburgh postnatal depression scale(EPDS)
