摘要
氮杂环化合物包括哒嗪、嘧啶、萘啶、异喹啉等结构。该骨架存在于Lenalidomide,Rosettacin,Oxypalmatime等活性分子中,其合成备受化学家的关注。金属催化的双环化反应是构建氮杂环骨架的常用方法,从单组分、两组分和多组分三个角度对该类反应进行叙述,将为稠合氮杂环化合物的合成提供新的思路。
Nitrogen heterocyclic compounds include pyridazine,pyrimidine,naphthyridine,isoquinoline and other structures.This skeleton exists in active molecules such as Lenalidomide,Rosettacin,Oxypalmatime,and its synthesis has attracted the attention of chemists.The metal-catalyzed bicyclization reaction is a common method to construct the nitrogen heterocyclic skeleton.This article describes this type of reaction from three perspectives of one-component,two-component and multi-component,which will provide new ideas for the synthesis of fused nitrogen heterocyclic compounds.
作者
范威
FAN Wei(Office of Research Affairs, Chuzhou City Vocation College, Chuzhou, Anhui 239000, China)
出处
《中州大学学报》
2021年第4期125-128,共4页
Journal of Zhongzhou University
基金
安徽省教育厅自然科学项目(KJ2020A1003)
滁州城市职业学院院级科研项目(2021zk07)。
关键词
金属催化
双环化反应
氮杂环骨架
metal catalysis
bicyclization reaction
nitrogen heterocycle skeleton
