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再生障碍性贫血后继发骨髓增生异常综合征1例

Aplastic anemia transformed to myelodysplastic syndrome:A case report
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摘要 再生障碍性贫血(aplastic anemia,AA)是一种免疫功能破坏造血干细胞/祖细胞导致的获得性造血功能衰竭性疾病,目前其具体机制仍未明确[1-2]。随着异基因造血干细胞移植以及免疫抑制剂疗效的不断提高,AA患者预后较前明显改观[3]。但仍有1.7%~15%的AA患者免疫抑制治疗疗效较差,并进展为骨髓增生异常综合征(myelodysplastic syndromes,MDS)/急性髓系白血病(acute myelocytic leukemia,AML)。
作者 蒙珊 陈社平 张龙进 王婷 王旭庚 蒙昕 田纬 赵万红 马肖容 王剑利 张王刚 何爱丽 陈银霞 MENG Shan;CHEN Sheping;ZHANG Longjin;WANG Ting;WANG Xugeng;MENG Xin;TIAN Wei;ZHAO Wanhong;MA Xiaorong;WANG Jianli;ZHANG Wanggang;HE Aili;CHEN Yinxia(Department of Hematology,the Second Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710004,China)
出处 《现代肿瘤医学》 CAS 北大核心 2021年第17期3100-3104,共5页 Journal of Modern Oncology
基金 陕西省自然科学基础研究计划青年基金项目(编号:2017JQ8044) 西安交通大学第二附属医院人才培养专项基金-科技新苗项目[编号:RC(XM)201709]。
关键词 再生障碍性贫血 骨髓增生异常综合征 JAK2 二代测序 aplastic anemia myelodysplastic syndrome JAK2 next-generation sequencing
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