摘要
随着全球气候变化和人类活动的增加,环境因素对人类健康的影响逐渐凸显。空气污染与气象因素作为环境因素的重要组成,对人类健康的影响引起了广泛关注。炎症免疫性疾病是一组引起多器官系统损伤的慢性炎症性疾病,主要受遗传因素和环境因素影响。近年来研究表明,颗粒物、二氧化氮、臭氧等空气污染物与炎症免疫性疾病的发病密切相关。然而,气象因素对这类疾病的影响尚不清楚。流行病学研究显示,气象因素与炎症免疫性疾病的发病和复发有关,但具体机制仍未阐明,可能为诱发氧化应激、炎症反应、促炎细胞因子的产生和T淋巴细胞失衡等,最终导致多器官、多系统损伤。此外,气象因素和空气污染物间的协同或拮抗作用,以及环境因素与遗传易感性的交互作用均可能影响炎症免疫性疾病的发生发展。本文主要概述了气象因素与常见炎症免疫性疾病之间的关联和可能的机制,以期为进一步揭示该类疾病的发病机制,制定综合性防制策略提供依据。
With the intensification of global climate change and human activities,the role of environmental factors in human health is gradually highlighted.Air pollution and meteorological factors,as the main components of environmental factors,have attracted widespread attention to their impact on human health.Inflammatory immune diseases are a group of chronic inflammatory diseases that cause damage to multiple organ systems and are mainly influenced by genetic and environmental factors.Recent studies have shown that the role of air pollutants such as particulate matter,nitrogen dioxide,and ozone are strongly associated with the onset of inflammatory immune diseases.However,the impact of meteorological factors on these diseases remains to be fully elucidated.A large number of epidemiological studies have shown that meteorological factors may induce onset and recurrence of inflammatory immune diseases.The specific mechanism is still not elucidated fully and probably includes oxidative stress,inflammation,production of proinflammatory cytokines,T cell imbalance,etc,eventually leading to multiple organ system damage.In addition,the synergistic or antagonistic effects of meteorological factors and air pollutants,as well as the interaction between environmental factors and genetic susceptibility may influence the development of inflammatory immune diseases.In this review,we summarized the epidemiologic and pathogenic evidence linking meteorological factors to common inflammatory immune diseases.The information obtained may be beneficial for further elucidating the pathogenesis of inflammatory immune disease and making proper preventive strategies for these diseases.
作者
陈悦
冷瑞雪
潘海峰
CHEN Yue;LENG Rui-xue;PAN Hai-feng(Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Inflammation and Immune Mediated Diseases Laboratory of Anhui Province,Hefei 230032,China)
出处
《中华疾病控制杂志》
CSCD
北大核心
2021年第8期879-884,992,共7页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(81872687,82073652,81872693)。
关键词
炎症免疫性疾病
气象因素
哮喘
慢性阻塞性肺疾病
自身免疫性疾病
Inflammatory immune disease
Meteorological factors
Asthma
Chronic obstructive pulmonary disease
Autoimmune disease
