摘要
蛋鸡脂肪肝出血综合征(fatty liver hemorrhage syndrome, FLHS)是一种常见的慢性营养代谢性疾病,主要受到营养、遗传、激素等多种因素的调控。患病后的鸡肝脏内会有大量脂肪沉积,产蛋量出现急速下滑,这极大地影响了养禽业的发展。目前,它的确切发病分子机制尚未明晰。现通过论述禽类脂质代谢特点,分析影响FLHS产生的可能因素及防治方法,并主要针对与FLHS有关的几种调控机制如AMPK、JAK-STAT及表观遗传调控的研究进展进行综述,以期为FLHS防治及未来的研究方向提供参考与思路。
Fatty liver hemorrhage syndrome(FLHS)is a common chronic nutritional metabolic disease,which is affected by nutrition,genetics,hormones and other factors during its development.Chickens with the disease will have large fat deposits in their livers and experience a sharp decline in egg production,which greatly affects the development of poultry industry.At present,the exact molecular mechanism of FLHS is still not clear.Thus,in this paper,the characteristics of lipids metabolism in poultry were discussed,the controlling methods and some possible factors affecting FLHS were analyzed,and the research progress of several regulatory mechanisms related to FLHS including AMPK,JAK-STAT and epigenetic regulation were introduced emphatically,so as to provide basic research data and pave a new road for preventing FLHS.
作者
曾文惠
曾庆节
殷超
杨小璇
王玉洁
茹盟
刘佳婷
谢贤华
梁海平
魏庆
黄建珍
ZENG Wenhui;ZENG Qingjie;YIN Chao;YANG Xiaoxuan;WANG Yujie;RU Meng;LIU Jiating;XIE Xianhua;LIANG Haiping;WEI Qing;HUANG Jianzhen(College of Animal Science and Technology,Jiangxi Agricultural University,Nanchang 330045,China)
出处
《中国兽医学报》
CAS
CSCD
北大核心
2021年第8期1658-1665,共8页
Chinese Journal of Veterinary Science
基金
国家自然科学基金资助项目(31960690,31460648)。
