摘要
目的调查持续非卧床腹膜透析(CAPD)患者症状群分类,分析其与透析充分性的相关性。方法方便抽样方法选取2018年10月至2019年12月在广西医科大学第一附属医院腹膜透析中心的180例CAPD患者,采用一般资料调查表、透析症状评估量表进行调查。结果乏力、口干、皮肤干燥、入睡困难、瘙痒为CAPD患者症状发生率前5位的症状,而瘙痒、入睡困难、头痛、下肢水肿、皮肤干燥5个症状为CAPD患者严重程度较高的症状。采用探索性因子分析,共提取5大症状群,分别为水电解质症状群、心理症状群、能量症状群、胃肠道症状群、皮肤症状群。Pearson相关分析显示,水电解质症状群与甲状旁腺素呈正相关(r=0.157,P<0.05),与24 h超滤量呈负相关(r=-0.157,P<0.05)。心理症状群与血尿素氮呈正相关(r=0.168,P<0.05);能量症状群与血磷、血尿素氮呈正相关(r=0.190、0.209,P<0.05或P<0.01),与血清白蛋白、24 h尿量呈负相关(r=-0.158、-0.263,P<0.05或P<0.01);胃肠道症状群与24 h尿量、总肌酐清除率呈负相关(r=-0.242、-0.244,P<0.01);皮肤症状群与血磷、血尿素氮、血肌酐、甲状旁腺素呈正相关(r=0.256、0.169、0.222、0.172,P<0.05或P<0.01),与24 h尿量、总肌酐清除率呈负相关(r=-0.382、-0.275,P<0.01)。结论CAPD患者经历多种症状,症状困扰程度高,症状之间构成症状群;症状群与透析充分性存在相关性。
Objective To investigate the symptom cluster classification of continuous ambulatory peritoneal dialysis(CAPD)patients and to analyze the correlation between symptom clusters and dialysis adequacy.Methods A total of 180 CAPD patients in the Peritoneal Dialysis Center of the First Affiliated Hospital of Guangxi Medical University from October 2018 to December 2019 were selected by convenience sampling method.The general information questionnaire and dialysis symptom assessment scale were used for the investigation.Results Fatigue,dry mouth,dry skin,difficulty sleeping and pruritus were the top five symptoms in the incidence of symptoms in CAPD patients,while pruritus,difficulty sleeping,headache,lower limb edema and dry skin were the most serious symptoms in CAPD patients.Exploratory factor analysis was used to extract five symptom groups,which were water and electrolyte symptom group,psychological symptom group,energy symptom group,gastrointestinal symptom group,and skin symptom group.Pearson correlation analysis showed that water and electrolyte symptom group was positively correlated with parathyroidin(r=0.157,P<0.05),and negatively correlated with 24 h ultrafiltration volume(r=-0.157,P<0.05).Psychological symptom group was positively correlated with blood urea nitrogen(r=0.168,P<0.05).The energy symptom group was positively correlated with serum phosphorus and blood urea nitrogen(r=0.190,0.209,P<0.05 or P<0.01),and negatively correlated with serum albumin and 24 h urine volume(r=-0.158,-0.263,P<0.05 or P<0.01).Gastrointestinal symptom group was negatively correlated with 24 h urine volume and total creatinine clearance(r=-0.242,-0.244,P<0.01).The skin symptom group was positively correlated with serum phosphorus,blood urea nitrogen,serum creatinine,and parathyroid hormone(r=0.256,0.169,0.222,0.172,P<0.05 or P<0.01),and negatively correlated with 24 h urine volume and total creatinine clearance(r=-0.382,-0.275,P<0.01).Conclusion CAPD patients experience a variety of symptoms with a high degree of distress,and t
作者
卢海珍
黄燕林
李浩宇
吴一平
杨震
王涵
陈国伟
LU Haizhen;HUANG Yanlin;LI Haoyu;WU Yiping;YANG Zhen;WANG Han;CHEN Guowei(Department of Nephrology,the Second Affiliated Hospital of Guangxi Medical University,Guangxi Zhuang Autonomous Region,Nanning530007,China;Department of Nephrology,the First Affiliated Hospital of Guangxi Medical University,Guangxi Zhuang Autonomous Region,Nanning530021,China)
出处
《中国医药导报》
2021年第22期104-108,共5页
China Medical Herald
基金
广西医疗卫生适宜技术开发与推广应用项目(S2017030)
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190666)。
关键词
持续非卧床腹膜透析
症状群
透析充分性
相关性
Continuous ambulatory peritoneal dialysis
Symptom cluster
Dialysis adequacy
Correlation
