摘要
目的探讨吴煜教授治疗中晚期肝癌的用药规律。方法选取2017年9月至2018年12月就诊于中国中医科学院西苑医院肿瘤科吴煜教授门诊的中晚期肝癌患者的中药处方为研究对象,采用中国中医科学院中医传承辅助平台(V2.5)统计药物使用频次、关联规则,应用复杂系统熵聚类进行核心药物的聚类分析,挖掘药物的核心组合及新处方。结果共纳入处方382首,使用药物共109味。最常用的3味药物分别为太子参(364)、茯苓(343)、浙贝母(336);药物组合前3位的依次是太子参-茯苓(337)、浙贝母-太子参(333)、浙贝母-茯苓(327)。置信度为1的关联药物共48组;通过聚类分析得到核心药物组合10组,新处方6首。结论吴煜教授治疗中晚期肝癌以健脾益气化痰为主,辅以理气祛瘀、散结解毒之品,标本兼顾,可供临床参考。
Objective To investigate the medication rules of Professor Wu Yu in the treatment of advanced hepatocellular carcinoma.Methods Chinese medicine prescriptions of patients with advanced hepatocellular carcinoma treated in Outpatient Department of Professor Wu Yu in Xiyuan Hospital,China Academy of Chinese Medical Sciences from September 2017 to December 2018 were selected as research objects.Chinese medicine inheritance auxiliary platform of China Academy of Chinese Medical Sciences(V2.5)was used to count the drug use frequency and association rules,and the complex system entropy clustering was used for cluster analysis of core drugs to mine the core combinations and new prescriptions of drugs.Results A total of 382 prescriptions were included,and 109 Chinese medicines were used.Three most commonly used medicines were Pseudostellariae Radix(364),Poria(343)and Fritillariae Thunbergii Bulbus(336).The most commonly used medicine combinations were Pseudostellariae Radix-Poria(337),Fritillariae Thunbergii Bulbus-Pseudostellariae Radix(333)and Fritillariae Thunbergii Bulbus-Poria(327).There were 48 groups of associated medicines with confidence level of one.Ten core combinations and six new prescriptions were obtained by complex system entropy cluster analysis.Conclusion The mainly treatment method of advanced hepatocellular carcinoma by Professor Wu Yu is tonifying qi and spleen and resolving phlegm,mostly supplemented by regulating qi and removing stasis,resolving hard mass and removing toxicity.The method considers both manifestation and root cause,and it is useful for clinical reference.
作者
宋金洁
李中玉
郭中宁
吴煜
SONG Jinjie;LI Zhongyu;GUO Zhongning;WU Yu(Department of Oncology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)
出处
《中国医药导报》
2021年第24期124-127,共4页
China Medical Herald
基金
国家重点研发计划项目(2017YFC1700606)。
关键词
中晚期肝癌
用药规律
吴煜
中医传承辅助平台
数据挖掘
Advanced hepatocellular carcinoma
Medication rule
Wu Yu
Chinese medicine inheritance auxiliary platform
Data mining
