摘要
目的分析注射用烟酰胺药品不良反应(ADR)发生的特点和规律,促进临床合理用药。方法对2018年1月—2020年12月河南省上报国家药品不良反应监测系统的80例注射用烟酰胺药品不良反应进行分析。结果共计纳入ADR病例80例,其中新的ADR 28例(35.00%),50岁以上66例(82.50%),29例(36.25%)存在超适应证用药,49例(61.25%)ADR发生于输注过程中,ADR累及系统/器官以皮肤及其附件、全身性反应、消化系统、神经系统、心血管系统最常见。结论临床药师应掌握注射用烟酰胺ADR发生特点,提醒医师严格按照说明书要求用药,用药过程中密切监护,减少ADR对患者造成的损害。
Objective To analyze the general information and clinical characteristics of adverse drug reactions(ADR)induced by nicotinamide for injection to promote rational drug use.Methods Totally 80 reported ADRs in Henan Province between January 2018 and December 2020 were analyzed retrospectively.Results Totally 80 cases were collected,among which 28(35.00%)were new ADRs,66(82.50%)over 50 years old,29(36.25%)with off-label use,and 49(61.25%)occurred in the course of intravenous infusion.Injury of the skin,systematic injury,digestive system,nervous system,and cardiovascular system were the common clinical manifestations.Conclusion Clinical pharmacists should be aware of the characteristics of ADR induced by nicotinamide for injection,which should be used strictly in accordance with the instructions and monitored closely during the course of nicotinamide injection to reduce possible injuries to patients.
作者
景天闯
张丹
范晶晶
魏简汇
冯文华
JING Tian-chuang;ZHANG Dan;FAN Jing-jing;WEI Jian-hui;FENG Wen-hua(Nanyang Central Hospital,Nanyang Henan 473000;Nanyang Institute of Food and Drug Control,Nanyang Henan 473000)
出处
《中南药学》
CAS
2021年第8期1725-1728,共4页
Central South Pharmacy
基金
河南省医学科技攻关计划联合共建项目(No.LHGJ20191459)。
关键词
注射用烟酰胺
药品不良反应
合理用药
药学监护
nicotinamide
adverse drug reaction
rational drug use
pharmaceutical care
