期刊文献+

血浆TSG-6水平与扩张型心肌病心力衰竭患者心功能、心肌纤维化及预后的相关性 被引量:26

Correlation of plasma TSG-6 with cardiac function,myocardial fibrosis,and prognosis in dilated cardiomyopathy patients with heart failure
下载PDF
导出
摘要 目的:肿瘤坏死因子α刺激基因-6(tumor necrosis factorαstimulated gene 6,TSG-6)蛋白是一种炎症诱导蛋白质。近年来发现TSG-6蛋白在多种疾病模型中发挥了抗炎、抗纤维化作用。在循环血液中TSG-6蛋白水平目前被认为可作为评估急性冠脉综合征、重症感染等疾病的生物学指标,并与预后密切相关。TSG-6蛋白与扩张型心肌病(以下简称扩心病)心力衰竭(以下简称心衰)临床相关性研究鲜见报道。本研究旨在探讨扩心病心衰患者血浆TSG-6蛋白水平变化及其与心功能、心肌纤维化及预后的相关性。方法:采用前瞻性研究方法,连续选取2019年12月1日至2020年9月1于中南大学湘雅医院心内科住院的扩心病心衰患者90例作为扩心病心衰组,选择同期体检中心健康体检者39例作为对照组。采用ELISA法测定血浆TSG-6蛋白、Ⅰ型胶原蛋白(CollagenⅠ)、Ⅲ型胶原蛋白(Collagen Ⅲ)、α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)的水平。采用超声心动图评估心脏的结构和功能。对扩心病心衰组患者随访3个月,根据是否发生主要不良心血管事件(major adverse cardiovascular events,MACE),将患者分为发生MACE组及未发生MACE组。比较对照组与扩心病心衰组之间的一般临床资料,血浆TSG-6、CollagenⅠ、Collagen Ⅲ、α-SMA蛋白水平差异,同时分析扩心病心衰组内血浆TSG-6蛋白水平与患者心功能分级、心肌纤维化及预后的相关性。结果:与对照组相比,扩心病心衰组患者心率、TSG-6、CollagenⅠ、Collagen Ⅲ、α-SMA、血红蛋白、心房脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-pro-BNP)、超敏C反应蛋白、谷草转氨酶、血清肌酐、乳酸脱氢酶和左心室舒张末期内径(left ventricular end diastolic diameter,LVEDD)显著升高(均P<0.001),高密度脂蛋白、左心室短轴缩短率(left ventricular fractional shortening,LVFS)、左心室射血分数(left ventricular ejection fractions,LV Objective: Tumor necrosis factor α stimulated gene 6(TSG-6) protein is an inflammationinducing protein. In recent years, TSG-6 protein has been found to play an antiinflammatory and anti-fibrosis role in a variety of disease models. The level of TSG-6 protein in circulating blood is considered to be a biological indicator for the evaluation of acute coronary syndrome, severe infection, and other diseases, and it is closely related to the prognosis. The clinical correlation between TSG-6 protein and dilated cardiomyopathy(DCM) patients with heart failure has not been reported. This study aims to investigate the changes of plasma TSG-6 protein levels in cardiomyopathy patients with heart failure and its correlation with cardiac function, myocardial fibrosis, and prognosis.Methods: Based on the prospective studies, a number of 90 DCM patients with heart failure were selected as a DCM heart failure group from Dec. 1, 2019 to Sept. 1, 2020.Thirty-nine healthy people were served as a control group. Plasma TSG-6, Collagen Ⅰ,Collagen Ⅲ, and α-smooth muscle actin(α-SMA) were measured with ELISA test.Echocardiography was used to evaluate the structure and function of the heart. DCM patients with heart failure were followed up for 3 months. The patients were assigned into 2 groups according to whether they had major adverse cardiovascular events(MACE). The general clinical data, plasma TSG-6, Collagen Ⅰ, Collagen Ⅲ, and α-SMA protein levels were compared between the control group and the DCM heart failure group. At the same time, the correlation between plasma TSG-6 protein level and cardiac function grade,myocardial fibrosis or prognosis of patients in the DCM heart failure group was analyzed.Results: Compared with the control group, the heart rate, TSG-6, Collagen Ⅰ, Collage Ⅲ, α-SMA, hemoglobin, atrial natriuretic peptide(NT-pro BNP), hypersensitive C-reactive protein, aspartate aminotransferase, serum creatinine, lactate dehydrogenase, and left ventricular end diastolic diameter(LVEDD) increased signifi
作者 许丽君 张银妆 匡圆圆 方晗 马琦琳 XU Lijun;ZHANG Yizhuang;KUANG Yuanyuan;FANG Han;MAQilin(Department of Cardiology,Xiangya Hospital,Central South University,Changsha 410008,China)
出处 《中南大学学报(医学版)》 CAS CSCD 北大核心 2021年第7期689-696,共8页 Journal of Central South University :Medical Science
关键词 肿瘤坏死因子α刺激基因-6 扩张型心肌病 心力衰竭 心功能分级 主要不良心血管事件 tumor necrosis factor α stimulated gene 6 dilated cardiomyopathy heart failure cardiac functional classification major adverse cardiovascular events
  • 引文网络
  • 相关文献

同被引文献257

引证文献26

二级引证文献34

;
使用帮助 返回顶部