摘要
目的探究CD47、8⁃羟基脱氧鸟苷(8⁃OHDG)、Adropin蛋白对急性脑出血90 d临床预后的预测价值。方法选取本院90例急性脑出血患者,根据90 d临床预后分为预后良好组(21例)与预后不良组(69例),分析CD47、8⁃OHDG、Adropin蛋白预测90 d临床预后的价值。结果预后不良组血肿液CD47、血清8⁃OHDG水平高于预后良好组,Adropin蛋白水平低于预后良好组,差异均有统计学意义(P<0.05);血肿液CD47、血清8⁃OHDG与出血量、神经功能损伤程度、破入脑室呈正相关,Adropin蛋白与出血量、神经功能损伤程度、破入脑室呈负相关(P<0.05);将其他因素控制后,血肿液CD47、血清8⁃OHDG、Adropin蛋白仍与90 d临床预后显著相关(P<0.05);三者联合预测90 d临床预后的AUC为0.950,95%CI:0.883~0.985,敏感度为95.24%,特异度为85.51%,优于单独预测(P<0.05)。结论血肿液CD47、血清8⁃OHDG、Adropin蛋白能有效反映急性脑出血病情状况,联合检测可作为预测短期预后的重要途径。
Objective To explore the predictive value of CD47,8⁃hydroxydeoxyguanosine(8⁃OHDG)and adropin protein on the clinical prognosis of acute cerebral hemorrhage at 90 days.Methods Ninety patients with acute cerebral hemorrhage in our hospital were selected and divided into a good prognosis group(21 cases)and a poor prognosis group(69 cases)according to the 90⁃day clinical prognosis.The value of CD47,8⁃OHDG and adropin protein in predicting the clinical prognosis of 90 days was analyzed.Results The levels of hematoma fluid CD47 and serum 8⁃OHDG in the poor prognosis group were higher than those in the good prognosis group,and the adropin protein level was lower than that in the good prognosis group(P<0.05).Hematoma fluid CD47 and serum 8⁃OHDG were positively correlated with bleeding volume,nerve function damage,and penetration into the ventricle,and adropin protein was negatively correlated with bleed⁃ing volume,nerve function damage,and penetration into the ventricle(P<0.05).After controlling for other factors,CD47 in hematoma fluid,serum 8⁃OHDG,and adropin protein were still significantly related to the 90⁃day clinical prognosis(P<0.05).The AUC of the three combined predictions of the 90⁃day clinical progno⁃sis was 0.950,95%CI was 0.883⁃0.985,the sensitivity was 95.24%,and the specificity was 85.51%,which was better than the individual prediction(P<0.05).Conclusion Hematoma fluid CD47,serum 8⁃OHDG,and adropin protein can effectively reflect the condition of acute cerebral hemorrhage,and combined detection is an important way to predict short⁃term prognosis.
作者
苟志勇
谭华
朱黎
蒋正方
GOU Zhiyong;TAN Hua;ZHU Li;JIANG Zhengfang(Department of Neurosurgery,Sichuan Mianyang 404 Hospital,Mianyang,Sichuan,China,621000)
出处
《分子诊断与治疗杂志》
2021年第8期1317-1320,共4页
Journal of Molecular Diagnostics and Therapy
基金
四川省科技计划项目(2017JY0035)。
