摘要
Background:Dengue fever(DF)outbreaks present regionally specific epidemiological and clinical characteristics.In certain medium-sized cities(100000–250000 inhabitants)of São Paulo State,Brazil,and after reaching an incidence of 150 cases/100000 inhabitants(“epidemiological threshold”),clinical diagnosis indicated dengue virus(DENV)infection.During this period,other seasonally infectious diseases with symptoms and physical signs mimicking DF can simultaneously occur,with the consequential overcrowding of health care facilities as the principal drawbacks.Confirmation of clinical diagnosis of DF with serological tests may help in avoiding faulty diagnosis in patients,who might later undergo dengue hemorrhagic fever(DHF)and the dengue-shock syndrome(DSS).Furthermore,demographic and hematological profiles of patients are useful in detecting specific early characteristics associated to DF,DHF and DSS.Methods:From March to June,2007,456 patients from Marilia in northwest São Paulo State who had only been diagnosed for DF by clinical criteria,underwent serologic testing for non-structural 1(NS1)DENV antigens.Individual results were used in comparative analysis according to demographic(gender,age)and hematological(leukocyte and platelet counts,percentage of atypical lymphocytes)profiles.Temporal patterns were evaluated by subdividing data according to time of initial attendance,using recorded variables as predictors of DENV infection in logistic regression models and ROC curves.Results:Serologic DENV detection was positive in 70.6%of the patients.Lower leukocyte and platelet counts were the most important factors in predicting DENV infection(respective medians DENV+=3715 cells/ml and DENV-=6760 cells/ml,and DENV+=134896 cells/ml and DENV-=223872 cells/ml).Furthermore,all demographic and hematological profiles presented a conservative temporal pattern throughout this long-lasting outbreak.Conclusions:As consistency throughout the epidemic facilitated defining the conservation pattern throughout the early stages,thi
基金
This study received financial support from PRONEX/Dengue,CNPq,Grant number 550106/2010-3.
