摘要
目的检测一种新型国产人造血管材料抗血浆渗出及抗出血性能。方法健康的实验用藏猪1只,体重47 kg。全麻后于左侧第4肋间开胸,阻断胸降主动脉,采用双盲法将4款同样大小的补片分为对照组(2种商品化补片)和实验组(2种自研血管材料)补片随机缝至胸降主动脉的4个切口上,开放胸降主动脉后,分别测量正常血细胞比容(HCT)0.39时三种血压状态下(收缩压60~70 mmHg、90~100 mmHg及130~145 mmHg)和血液稀释状态(HCT 0.31、收缩压130~145 mmHg)下补片表面渗血渗液数据,调控血压方法为血管活性药物+胸降主动脉部分阻断。结果手术阻断时间:35 min。在正常HCT下,收缩压为60~70 mmHg时,两个实验组渗出均少于对照1组,差异有统计学意义(P<0.05);在收缩压为90~100 mmHg及130~145 mmHg时实验组与对照组渗血渗液量无明显差异(P>0.05);相同血压(收缩压为130~145 mmHg),血液稀释状态(HCT为0.31)下与正常状态(HCT为0.39)时的补片渗血渗液无明显差异(P>0.05)。结论在凝血功能正常的情况下,新型的国产人造血管材料即刻的抗血浆滲出及抗出血性能可能优于对照1组;随着自身凝血成分在人造血管内壁的附着,不同血压、HCT状态下,该新型的国产人造血管材料抗血浆渗出及抗出血性能与其他两种已商品化的人造血管可能无差别;同一血压状态下,HCT的变化对人造血管的渗出影响不明显;明确的结论尚需更多的实验病例验证。
Objective To investigate the anti-plasma exudation and anti-bleeding performance of a new type of domestic artificial vascular material.Methods One healthy Tibetan pig with the body weight of 47 kg was used in the experiment.After general anesthesia,the left 4th intercostal thoracotomy was performed to cross clamp the descending thoracic aorta.The 4 types of patches of the same size were divided into the control group(2 kinds of commercial patches)and the experimental group(2 kinds of self-developed vascular materials)by double-blind method,and the patches were randomly stitched to the 4 incisions of the descending thoracic aorta.After opening the descending thoracic aorta,the amount of blood exudation on the patch surface was measured under three blood pressure values(SBP 60-70 mmHg,90-100 mmHg and 135-145 mmHg)with normal hematocrit(HCT 39%)and a state of hemodilution(HCT 31%,sBp130-145 mmHg).Blood pressure was controlled by vasoactive drugs and partial occlusion of descending thoracic aorta.Results The cross clamp time was 35 min.Under normal HCT and SBP of 60-70 mmHg,the exudation of the two experimental groups was less than that of the control group 1,and the difference was statistically significant(P<0.05).When the SBP was 90-100 mmHg and 130-145 mmHg,there was no significant difference in the amount of exudation between the experimental group and the control group(P>0.05).There was no significant difference in patch exudation between the normal HCT(39%)and the hemodilution(31%)state under the same blood pressure(SBP130-145 mmHg)(P>0.05).Conclusion Under the condition of normal coagulation function,the immediate anti-plasma exudation and anti-bleeding properties of the new domestic artificial vascular material maybe superior to those of the control group 1.With the attachment of coagulation components to the inner wall of the artificial blood vessel,the anti-plasma exudation and anti-bleeding performance of the new domestic artificial blood vessel material is no different from that of the other two commerci
作者
张程
王鹏程
吴柯叶
丁以群
Zhang Cheng;Wang Pengcheng;Wu Keye;Ding Yiqun(Department of Cardiothoracic Surgery,Shenzhen Children's Hospital,Guangdong Shenzhen 518038,China)
出处
《中国体外循环杂志》
2021年第4期235-238,共4页
Chinese Journal of Extracorporeal Circulation
基金
深圳市医学重点学科建设经费资助(SZXK036)
深圳市三名工程基金(SZSM201612003)
广东省医学科学技术研究基金项目(A2020204)
深圳市科创委基础研究面上项目(JCYJ20190809170811489)。
关键词
新型国产人造血管
抗出血性能
动物实验
Novel domestic artificial blood vessel
Anti-bleeding performance
Animal experiment
