摘要
目的探讨依那普利联合缬沙坦治疗糖尿病肾病(DN)伴高血压患者对血压及血清炎症因子的影响。方法选取2018年7月~2020年7月我院收治的123例DN伴高血压患者为研究对象,采用随机数字法将其分为对照组(n=61)和观察组(n=62)。对照组给予依那普利治疗,观察组给予依那普利联合缬沙坦治疗。比较两组血糖[空腹血糖(FPG)、餐后2 h血糖(P2hBG)、糖化血红蛋白(HbA1c)]、24 h血压[收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)]、肾功能[24 h尿蛋白定量(24 h UPr)、肌酐(Scr)、尿素氮(BUN)、血钾]、血清炎症因子[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、C反应蛋白(CRP)]水平及不良反应发生率。结果治疗后,观察组24 h SBP、24 h DBP、24 h MAP水平低于对照组(P<0.05);治疗后,观察组24 h UPr、Scr、BUN水平低于对照组(P<0.05);治疗后,观察组血清TNF-α、IL-6、CRP水平低于对照组(P<0.05);两组FPG、P2hBG、HbA1c水平和不良反应发生率比较,差异无统计学意义(P>0.05)。结论依那普利联合缬沙坦治疗DN伴高血压效果较好,可降低血压及血清炎症因子水平,保护肾功能,且安全性较高。
Objective To analyze the effects of enalapril combined with valsartan in the treatment of diabetic nephropathy(DN)combined with hypertension on blood pressure and serum inflammatory factors.Methods A total of 123 patients with DN and hypertension who were admitted to the hospital from June 2018 to June 2020 were enrolled as subjects,and they were divided into control group(n=61)and observation group(n=62)by random number method.The group was treated with enalapril,while observation group was treated with enalapril and valsartan.The levels of blood glucose[fasting blood glucose(FPG),2h postprandial blood glucose(P2hBG),glycosylated hemoglobin(HbA1c)],24h blood pressure[systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arterial pressure(MAP)],renal function[24h urine protein(24h UPr),creatinine(Scr),blood urea nitrogen(BUN),potassium]and serum inflammatory factors[tumor necrosis Factor-α(TNF-α),interleukin-6(IL6),C-reactive protein(CRP)],and the incidence of adverse reactions were compared between the two groups.Results After treatment,levels of 24h SBP,24h DBP and 24h MAP in observation group were lower than those in control group(P<0.05),levels of 24h UPr,Scr and BUN were lower than those in control group(P<0.05),and levels of TNF-α,IL-6 and CRP were lower than those in control group(P<0.05).There were no significant differences in the levels of FPG,P2hBG and HbA1c,and the incidence of adverse reactions between the two groups(P>0.05).Conclusion The curative effect of enalapril combined with valsartan is good on DN combined with hypertension,which can reduce levels of blood pressure and serum inflammatory factors,and protect renal function,with high safety.
作者
王娅敏
刘智美
苟玉竹
薛莲
WANG Yamin;LIU Zhimei;GOU Yuzhu;XUE Lian(West China School of Nursing, Sichuan University, Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China)
出处
《西部医学》
2021年第8期1199-1202,共4页
Medical Journal of West China
基金
四川省科技厅应用基础研究项目(2018YJ0132)。
关键词
糖尿病肾病
高血压
依那普利
缬沙坦
血压
血清炎症因子
Diabetic nephropathy
Hypertension
Enalapril
Valsartan
Blood pressure
Serum inflammatory factor
