摘要
目的采用两样本孟德尔随机化方法探索肺功能与新型冠状病毒肺炎(COVID-19)病死风险之间的因果关联。方法对基于全基因关联研究(GWAS)的汇总数据进行二次数据分析。利用大样本GWAS汇总数据,选择与肺功能密切关联的遗传位点作为工具变量,分别用逆方差加权法、MR-Egger回归和加权中位数法做两样本孟德尔随机化分析,以OR值评价肺功能与COVID-19病死风险之间的因果关系。结果共纳入287个单核苷酸多态性作为工具变量,MR-Egger回归结果表明基因多效性不会对结果造成偏倚(P=0.107)。逆方差加权法结果显示,肺功能每增加一个标准差,会导致COVID-19患者病死风险降低62%(OR=0.38,95%CI:0.18~0.80)。MR-Egger回归也得到了相似的结果(OR=0.08,95%CI:0.01~0.61)。加权中位数法结果显示肺功能与COVID-19病死风险之间关联无统计学意义(OR=0.44,95%CI:0.14~1.42)。结论肺功能与COVID-19病死风险之间可能存在负向因果关联。
Objective To investigate whether lung function was causally associated with risk of fatality of COVID-19 based on a two-sample Mendelian randomization study.Methods This two-sample Mendelian randomization study used summary-level datasets of genome-wide association studies(GWAS)of forced vital capacity(FVC)and risk of fatality of COVID-19 from the UK Biobank.Inverse-variance weighted(IVW),MR-Egger regression,and weighted median estimator(WME)were conducted to investigate the association of lung function with risk of fatality of COVID-19,in which the OR values were used as indicators.Results A total of 287 single nucleotide polymorphisms were enrolled as instrumental variables.Statistically significant directional pleiotropy was not found(P=0.107).IVW regression demonstrated that per 1 elevated SD of FVC resulted in decreasing 62%of fatality risk in COVID-19 patients(OR=0.38,95%CI:0.18-0.80).MR-Egger regression also obtained a similar effect(OR=0.08,95%CI:0.01-0.61).WME analysis showed no significant association of FVC with risk of fatality of COVID-19(OR=0.44,95%CI:0.14-1.42).Conclusion Lung function might be negatively related to risk of fatality of COVID-19.
作者
杨璇
李岩志
马伟
贾崇奇
YANG Xuan;LI Yanzhi;MA Wei;JIA Chongqi(Department of Epidemiology,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan 250012,Shandong,China)
出处
《山东大学学报（医学版）》
CAS
北大核心
2021年第7期104-111,共8页
Journal of Shandong University:Health Sciences
