摘要
目的分析北京市顺义区妇幼保健院2014—2018年儿童及青少年手足口病原学监测结果,为制定有效的手足口病防控措施提供科学依据.方法采集定点监测医院诊断为手足口病的咽拭子,应用RT-PCR技术进行病原学分析.结果2014—2018年发热、咽峡部疱疹病例比例逐年增多,2018年最高.2015—2016年发热、咽峡部疱疹病例比例之间差异无统计学意义(P>0.05),其余各年之间差异均有统计学意义(P<0.05).共采集咽拭子653例,检出阳性结果572例,阳性率87.6%,其中EV71138例,CA16173例,CA6164例,肠道病毒其他型别97例.2014—2018年,各年病例中检出阳性率之间差异无统计学意义(P>0.05),但是各年阳性检出病例中病原构成比之间差异有统计学意义(P<0.05),2014年以EV71(45.9%)和CA16(30.3%)为主,2015年以CA16(24.6%)、CA6(23.9%)和EV其他(26.8%)为主,2016年以EV71(25.3%)和CA16(41.6%)为主,2017年及2018年以CA6(43.3%和54.5%)为主.结论顺义区手足口病的主要病原体每年存在差异,应加强当地儿童手足口病的病原学监测,为手足口病防治提供明确的病原学依据.
Objective The results of HFMD etiology surveillance in children and adolescents in Shunyi District of Beijing from 2014 to 2018 were analyzed to provide a scientific basis for the development of effective HFMD prevention and control measures in Shunyi District.Methods Throat swab samples for clinically diagnosed cases of HFMD were collected and the pathogens were analyzed by PCR technology.Results The proportion of fever cases and throat herpes cases increased year by year,with the highest in 2018.Except that there was no statistically significant difference between 2015 and 2016(P>0.05),the differences between other years were statistically significant(P<0.05).The 653 pharyngeal swabs were collected,and 572 of them were positive,with a positive rate of 87.59%,and including 138 cases of EV71,173 cases of CA16,164 cases of CA6 and 97 cases of other enterovirus types.There was no significant difference in the positive rate between cases(P>0.05),but there was significant difference in the composition ratio of each pathogen detected in cases of different genders each year from 2014 to 2018(P<0.05).EV71(45.9%)and CA16(30.3%)were the main pathogens in 2014,and CA16(24.6%),CA6(23.9%)and other EV(26.8%)were the main pathogens in 2015,and EV71(25.3%)and CA16(41.6%)were the main pathogens in 2016,and CA6 was the main pathogen in 2017 and2018(43.3%and 54.5%).Conclusion The main pathogens of HFMD vary each year,and the etiological monitoring of HFMD among local children should be strengthened to provide a clear etiological basis for the prevention and treatment of HFMD.
作者
唐智超
李红霞
Tang Zhichao;Li Hongxia(The Shunyi District Maternal and Child Health Care Centers of Beijing City,Beijing 101300;The Shunyi District Center for Disease Control and Prevention of Beijing City,Beijing 101300)
出处
《基层医学论坛》
2021年第23期3373-3375,共3页
The Medical Forum
关键词
儿童/青少年
手足口病
病原体
监测
Children/Teenager
Hand-foot-mouth disease
Pathogen
Monitor
