摘要
目的探讨血小板反应蛋白-1(TSP-1)在新生儿颅内出血、窒息及肺炎等疾病中的含量及其意义。方法选取2019年1月至2020年3月期间西安交通大学第一附属医院新生儿科收治的109例新生儿,其中颅内出血组34例,窒息组26例,肺炎组32例;选取同期入院的晚期早产儿或足月新生儿,均未合并颅内出血、窒息、肺炎及其他严重合并症的17例患儿为对照组。采用酶联免疫吸附法测定各组的血浆TSP-1含量,并比较各组血小板计数的变化情况。结果与对照组比较,颅内出血组血浆TSP-1含量显著降低(t=3.937,P<0.001),窒息组血浆TSP-1含量显著升高(t=2.826,P<0.01),肺炎组血浆TSP-1含量显著升高(t=9.711,P<0.001)。另外,各病例组患儿血小板数量与对照组比较差异均无统计学意义(P>0.05)。对照组、颅内出血组、窒息组、肺炎组的血浆TSP-1水平与血小板计数均无相关性(r分别为0.166、0.298、0.215、0.194,P>0.05)。结论血浆TSP-1含量可能对预测新生儿颅内出血风险、评估窒息脑损伤程度及辅助肺炎早期诊断有一定的指导意义。
Objective To explore the content and significance of thrombospondin-1(TSP-1)in neonates with intracranial hemorrhage,asphyxia and pneumonia.Methods 109 newborns treated in the Department of Neonatology,the First Affiliated Hospital of Xi′an Jiaotong University from January 2019 to March 2020 were selected,including 34 cases in the intracranial hemorrhage group,26 cases in the asphyxia group,and 32 cases in the pneumonia group.17 cases of late preterm infants or full-term neonates who were treated in the hospital during the same period,without intracranial hemorrhage,asphyxia,pneumonia,and other serious complications,were selected as the control group.Enzyme-linked immunosorbent assay was used to determine the plasma TSP-1 content in each group,and the changes in platelet counts in each group were compared.Results Compared with the control group,the content of TSP-1 in the intracranial hemorrhage group was significantly decreased(t=3.937,P<0.001),the content of TSP-1 in the asphyxia group was significantly increased(t=2.826,P<0.01),and the content of TSP-1 in the pneumonia group was significantly increased(t=9.711,P<0.001).In addition,there was no significant difference of the platelet counts between the patients in each case group and the control group(P>0.05).There was no correlation between plasma TSP-1 levels and platelet counts in the control group,intracranial hemorrhage group,asphyxia group and pneumonia group(r=0.166,0.298,0.215 and 0.194,respectively,all P>0.05).Conclusion It is suggested that the plasma TSP-1 content may have certain guiding significance for predicting the risk of neonatal asphyxia,assess the degree of asphyxia brain damage and assist the early diagnosis of pneumonia.
作者
宁芬茹
肖谧
林晓洁
王芳会
吴芳
周熙惠
NING Fenru;XIAO Mi;LIN Xiaojie;WANG Fanghui;WU Fang;ZHOU Xihui(Department of Neonatology,the First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xiran 710061,China)
出处
《中国妇幼健康研究》
2021年第7期963-967,共5页
Chinese Journal of Woman and Child Health Research
基金
国家自然科学基金资助项目(81100456)。
