摘要
目的探讨进展性脑卒中和短暂性脑缺血发作采用盐酸替罗非班治疗的效果。方法选择进展性脑卒中和短暂性脑缺血发作患者100例,均为巨野县人民医院神经内科2017年6月至2019年6月收治,采用数字表抽取法随机分组,就应用常规方案治疗(对照组,n=50)与加用盐酸替罗非班治疗(观察组,n=50)后两组患者的凝血功能指标、神经功能评分、药物不良反应率、复发性卒中占比展开对比。结果两组治疗前,凝血功能指标APTT、PLT、PT、PECAM-1差异无统计学意义(P>0.05);治疗后,APTT、PLT、PT指标均变化不明显,差异无统计学意义(P>0.05);但PECAM-1指标明显高于治疗前,且观察组明显高于对照组,差异具有统计学意义(P<0.05)。两组治疗前,神经功能评分差异无统计学意义(P>0.05),治疗后,神经功能评分均有降低,且观察组有更为明显的降低程度,差异具有统计学意义(P<0.05)。结论进展性脑卒中和短暂性脑缺血发作在常规治疗基础上,加用盐酸替罗非班,可改善血小板聚集现象,促进神经功能恢复,且未出现严重不良反应,可降低卒中复发风险,应用价值十分突出。
Objective:To investigate the value of tirofilban hydrochloride in the treatment of progressive stroke and transi-ent ischemic attack.Methods;100 patients with Progressive stroke and transient ischemic attack from the Department ofNeurology in June 2017 to June 2019 were analyzed,randomized digital table method was used to divide the observationgroup(control group,n=50)and hydrochloric acid treatment group(observation group,n=50)coagulant function index,nerve function score,the rate of adverse dnug reactions,recuent stroke were detected for comparison.Results;Before thetreatment,there was no statistically significant difference between the two groups in coagulation function indexes APTT,PLT,PT and pecam-l(P<0.05),no significant changes were observed in the APTT,PLT and PT indexes after the treat-ment(P>0.05);However,the pecam-l index was significantly higher than that before treatment,and the observationgroup was significantly higher than that of the coutrol group,with statistically significant differences(P<0.05).There wasno difference in neurological function scores between the two groups bfore treatment(P>0.05).After treatment,the8cores were all reduced,and there was a more significant reduction in the observation group,with statistically significantdifferences(P<0.05).Conclusion;Tinofebanja hydrochloride on the basis of conventional treatment can improve plateletaggregation,promote the recovery of nerve function,and reduce the risk of stroke recurence without serious adverse rac-tions for progressive stroke and transient ischemic attack.
作者
马福静
Ma Fujing(Peoples Hospital of Juye County,Heze274900,China)
出处
《山东第一医科大学（山东省医学科学院）学报》
2021年第6期457-459,共3页
Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences
关键词
进展性脑卒中
短暂性脑缺血发作
盐酸替罗非班
凝血功能指标
卒中复发
progressive stroke
transient ischemic attack
tirofiban hydrochloride
coagulation function index
recur-rence of stroke
