摘要
目的探讨周围血中胃饥饿素(Ghrelin)及中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的水平变化与急性胰腺炎(AP)患者病情转归的关系。方法分析2019年10月—2020年9月宁阳县第一人民医院收治的75例急性胰腺炎患者资料,包括急性轻症胰腺炎41例(MAP组)和急性重症胰腺炎34例(SAP组),全部患者于入院后即刻采集静脉血2ml,离心分离血清,超低温保存后备检。比较两组患者入院后第1天血清Ghrelin及NGAL水平的差异与病情轻重之间的关系。结果急性重症胰腺炎组患者的血清Ghrelin、NGAL水平均明显高于急性轻症胰腺炎组患者,差异具有统计学意义(P<0.001)。结论急性胰腺炎患者早期血清Ghrelin、NGAL水平与病情程度密切相关,两者水平增高提示患者预后不良,值得临床医师关注。
Objective:To investigate the relationship between the levels of Chrelin and neutrophil gelatinase-a5sociatedlipid lipocalin(NCAL)in peripheral blood and the pognosis of patients with acute pancreatitis(AP).Methods;To analyzrethe data of 75 acute pancreatitis patients admilted to Ningyang County First Peoples Hospital from October 2019 to September 2020,including 4l cases of acute mild pancreatitis(MAP group)and 34 cases of acute severe pancreatitis(SAP group).2mlvenous bloodl was collected immediately after admission in the whole group,and the serum was separated by centrfugation,and stored in ultra-low temperature for backup test.The differences of serum Chrelin anmd NGAL levels on the first day afteradmission were compared between the two groups.Results:The serum Chrelin and NCAL levels of patients in the acute severe pancreatitis group were significantly higher than those in the acute mild pancreatitis group,with statistically significantdifferences(P<0.001).Conclusion;The early serum levels of Chrelin and NCAL.in patients with acute pancreatitis areclosely related to the severity of the disease,and the increased serum levels of Chrelin and NCAL.suggest a poor pmognosisand deserve clinicians attention.
作者
戴文玲
Dai Wenling(Dept.of Internal Medicine,Ningyang County First Peoples Hospital,Ningyang 271400,China)
出处
《山东第一医科大学（山东省医学科学院）学报》
2021年第6期454-456,共3页
Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences
