摘要
目的对PDD患者应用盐酸美金刚治疗,并观察其治疗效果。方法选取2018年8月—2020年7月在平顶山市第二人民医院治疗的93例PDD患者,采取随机数字表法,将其分为两组。对照组46例,采取常规治疗(多巴丝肼片+盐酸多奈哌齐片);观察组47例,在此基础上,联合使用盐酸美金刚治疗。对比两组患者的认知功能(MoCA量表、MMSE量表)、日常生活能力(ADL量表)、不良反应。结果观察组患者治疗后的MoCA评分、MMSE评分、ADL评分均明显高于对照组,差异有统计学意义(P<0.05);观察组、对照组患者不良反应率分别为13.04%、17.02%,差异无统计学意义(P>0.05)。结论在常规治疗基础上,对PDD患者应用盐酸美金刚治疗可更好地改善患者认知功能,提高其生活能力,且不会增加不良反应。
Objective:To treat PDD patients with memantine hydrochloride and observe its therapeutic effect.Methodls:Atotal of 93 PDD patients treated in our hospital were selected and the cases from August 2018 to July 2020 were included,and they were divided into two groups.46 cases in the control group received conventional treatment(dopaserzide tablets+donepezil hydrochloride tablets);47 cases in the observation gnoup were treated wih memantine hydrochloride in combina-tion on the conventional basis.The cognitive function(MoCA scale,MMSE scale),ability of daily living(ADL scale),and adverse reactions of the two groups were compared.Results;After treatment,the MoCA score,MMSE score and ADL.score of the observation group were significantly higher than those of the control group(P<0.05);the adverse reactionrates of the observation group and control group were 13.04%and 17.02%,respectively,with no significant dlference(P>0.05).Conclusion;On the basis of conventional treatment,the application of memantine hydrochloride treatment to PDDpatients can better improve the cognitive function of patients,improve their living ability,and will not increase adverse re-actions.
作者
王志强
胡雅坤
李艳华
Wang Zhiqiang;Hu Yakun;Li Yanhua(The First Dept.of Neurology,Pingdingshan Second Peoples Hospital,Pinglingshan 467000,China)
出处
《山东第一医科大学（山东省医学科学院）学报》
2021年第6期433-435,共3页
Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences
基金
2019年河南省医学科技攻关计划联合共建项目(LHGJ20191261)。
关键词
帕金森痴呆
认知功能
盐酸美金刚
Parkinsons dementia
cognitive function
memantine hydrochloride
