摘要
目的探讨联合治疗对老年原发性高血压合并腹型肥胖者的降压疗效及外周血管病防治作用。方法将入选的127例受试者分为联合治疗组65例(A组)和缬沙坦组62例(B组)。两组均给予缬沙坦(80mg/d)进行降压治疗,联合治疗组在此基础上给予瑞舒伐他汀(10mg/d)。随访6个月。结果①治疗后,两组间的SBP、DBP、PP、TG、TC、LDL-c、AI较治疗前明显降低(P<0.05),HDL-c、ABI明显升高(P<0.05),且联合治疗组的变化程度大于缬沙坦组(P<0.05)。②治疗时两种药物对老年肥胖合并高血压患者的SBP、DBP、PP、ABI、AI存在交互作用,F值分别为21.599、3.167、42.845、59.633、27.506,其差异均有统计学意义(P<0.05)。③分组(治疗方法)与SBP、DBP、TG、TC、ABI、AI存在正相关(r_(1)=-0.453,r_(2)=-0.311,r_(3)=-0.228,r_(4)=-0.259,r_(5)=-0.426,r_(6)=-0.381,P<0.05)。结论联合治疗对老年高血压伴肥胖者降压疗效显著,能有效调节血脂水平,充分改善外周血管动脉硬化程度,预防和控制动脉硬化疾病的发生与发展。
Objective:To observe the antihypertensive effect of combined therapy on aged patients with primary hyper-tension and abdominal obesity and the prevention and treatment of peripheral vascular disease.Methods:A total of 127 elderly patients were enolled and divided into two groups,namely,the intensified therapy group(Valsrtan 80 mg/d,Rosuvastatin 10 mg/d,n=65),and the valsartan treatment group(Valsartan 80 mg/d,n=62).Regular follow-up was conducted for 6 months.Results:①After treatment,the SBP,DBP,PP,TG,TC,LDL-c and ABl of each group were significant ly lower than those before(P<0.05),HDL-c and ABl were significantly higher than those before trealtment(P<0.05),and the intensified therapy group was better than the valsartan group.The antihypertensive efficiency of combined antily-periensive group was higher than that of valsartan group(P<0.05).②There was interactive effect of antihypertensive andlipid lowering therapy in lowering SBP,DBP,PP,ABI and AI(P<0.05).③Partial correlation analysis showed thatthere was a positive correlation between treatment method and SBP,DBP,TG,TC,ABl and Al(P<0.05).Conclusion:Combined treatment has a significant effect on hypertension and obesity in the elderly,effectively regulating blood lipid levels,fully improving the degree of peripheral vascular arteriosclerosis,and preventing and controllig the occurrence and development of arteriosclerosis diseases.
作者
李兴超
王友芳
朱晓松
赵颖馨
李巾魁
相然
张蒙蒙
张金岭
车峰远
Li Xingchao;Wang Youfang;Zhu Xiaosong;Zhao Yingxin;Li Jinkui;Xiang Ran;Zhang Mengmeng;Zhang Jinling;Che Fengyuan(Office of Acadlemic Research of Linyi Peoples Hospital,Cheeloo College of Medicine,Shandong University,Linyi 276002,China;Intensive Care Unit of Linyi Peoples Hospital,Cheeloo College of Medicine,Shandong University,Linyi 276002,China;Infection Management Department of Linyi Peoples Hospital,Cheeloo College of Medicine,Shandong Universit,Linyi 27602,China;Institute of Basic Medicine,Shandong Academy of Medical Sciences,Jinan 250062,China;Internal Medicine of Peoples Hospital of Lanshan district,Linyi 276002,China)
出处
《山东第一医科大学（山东省医学科学院）学报》
2021年第6期415-419,共5页
Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences
基金
国家自然科学基金(82003435)
山东省自然科学基金(ZR2014HL062,ZR2020QH332)
山东省医药卫生科技发展计划(2018WS400)。
关键词
联合治疗
老年
肥胖
原发性高血压
外周血管病
the intensified therapy
elderly
obesity
essential hypertension
peripheral vascular disease
