摘要
Introduction:Parkinson's disease PD is a common neurodegenerative disorder mainly characterized by the progressive decline of motor function with a prevalence that is greatly increasing since the pathology is principally driven by aging.The currently available treatments only mitigate motor symptoms;therefore,a great deal of studies are aimed at finding novel drugs that are able to arrest the evolution of the disease.The progressive death of nigrostriatal dopaminergic(DA)neurons and the formation of the typical Lewy bodies neuronal inclusions containing misfolded alpha-synuclein are two key histopathological features of the disease.However,it is now evident that PD has to be considered as a heterogeneous disorder that includes subtypes with distinctive clinical and biological characteristics(Ryden and Lewis,2019).
基金
supported by grants from the University of Brescia。
