摘要
目的系统评价腰痛宁胶囊对比痹痛宁胶囊治疗腰椎骨性关节炎的有效性与安全性。方法计算机检索PubMed、Embase、Cochrane图书馆、万方数据库、中国知网数据库和维普数据库,收集腰痛宁胶囊对比痹痛宁胶囊治疗腰椎骨性关节炎的随机对照试验(RCT),提取相关资料并按照Cochrane 5.1.0手册的质量评价标准评价文献质量,采用Review Manager 5.3软件对其总有效率、日本骨科协会评估治疗分数(JOA)评分、疼痛视觉模拟评分(VAS)评分、功能障碍指数(ODI)评分、血清学指标[基质金属蛋白酶3(MMP-3)水平,白细胞介素1β(IL-1β)水平]及安全性指标进行Meta分析。结果符合纳入标准的RCT研究共有5项,涉及患者533例,其中试验组有265例,对照组268例。Meta分析结果显示,试验组总有效率[RR=1.26,95%CI(1.15,1.38)]和JOA评分[MD=4.60,95%CI(0.91,8.28)]均显著高于对照组(P<0.05);静息痛VAS评分[MD=-0.97,95%CI(-1.24,-0.70)]、活动痛VAS评分[MD=-1.16,95%CI(-1.61,-0.71)]、ODI评分[MD=-4.26,95%CI(-5.99,-2.52)],以及血清中IL-1β[MD=-3.17,95%CI(-4.86,-1.49)]和MMP-3[MD=-13.54,95%CI(-15.69,-11.39)]水平均明显低于对照组(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论腰痛宁胶囊对比痹痛宁胶囊在治疗腰椎骨性关节炎总有效率高,可更好抑制炎症、减轻疼痛、缓解腰椎功能障碍。
Objective To systematically evaluate the effectiveness and safety of Yaotongning Capsules(腰痛宁胶囊) versus Bitongning Capsules(痹痛宁胶囊) in the treatment of lumbar osteoarthritis. Methods Electronic databases including PubMed, Embase, Cochrane Library, Wanfang, CNKI and VIP database were searched for randomized controlled trials(RCTs) comparing Yaotongning Capsules to Bitongning Capsules in the treatment of lumbar osteoarthritis, and relevant data were extracted and analyzed. The quality of the literature was evaluated according to the Cochrane 5.1.0 manual. RevMan 5.3 software was used to perform meta-analyses on the total effective rate, the Japanese Orthopaedic Association(JOA) score, the visual analog scale(VAS) score, the Oswestry dysfunction index(ODI) score, the serological indicators including matrix metalloproteinase 3(MMP-3) level, interleukin 1β(IL-1β) level, and safety indicators. Results Five RCTs involving 533 patients were included with 265 patients in the treatment group and 268 in the control group. Meta analyses showed that the total effective rate(RR = 1.26, 95%CI 1.15 to 1.38) and JOA score(MD = 4.60, 95%CI 0.91 tof 8.28) were significantly higher in the treatment group than those in the control group(P<0.05);the resting pain VAS score(MD=-0.97, 95% CI-1.24 to-0.70), active pain VAS score(MD=-1.16, 95% CI-1.61 to-0.71), ODI score(MD=-4.26, 95%CI-5.99 to-2.52), serum IL-1β(MD=-3.17, 95%CI-4.86 to-1.49) and MMP-3(MD=-13.54, 95%CI-15.69 to-11.39) levels were significantly lower in the treatment group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Compared to Bitongning Capsules, Yaotongning Capsules have a higher total effective rate in treating lumbar osteoarthritis, which can better inhibit inflammation, relieve pain, and relieve lumbar spine dysfunction.
作者
郑雅
陈琛
刘志强
王博龙
ZHENG Ya;CHEN Chen;LIU Zhiqiang;WANG Bolong(School of Chemistry and Biological Engineering,Yichun University,Jiangxi Province,336000;Affiliated Hospital of Hebei University;Hebi Polytechnic,Henan Province)
出处
《中医杂志》
CSCD
北大核心
2021年第15期1326-1331,共6页
Journal of Traditional Chinese Medicine
关键词
腰椎骨性关节炎
腰痛宁胶囊
痹痛宁胶囊
系统评价
lumbar osteoarthritis
Yaotongning Capsules(腰痛宁胶囊)
Bitongning Capsules(痹痛宁胶囊)
systematic review
