摘要
目的观察解痉散瘀汤对椎动脉型颈椎病患者椎-基底动脉血流速度和脑血流量的影响。方法选取2018年3月—2019年12月北京中医药大学东直门医院收治的64例椎动脉型颈椎病患者,按照随机平行分组法分为对照组与观察组各32例。对照组应用盐酸氟桂利嗪胶囊以及尼莫地平片进行常规治疗,观察组在对照组治疗基础上加用解痉散瘀汤治疗。2组均连续治疗4周,观察2组治疗前后眩晕症状评分,中医症状积分,左椎动脉、右椎动脉、基底动脉收缩期峰值血流速度(Vs)、舒张期血流速度(Vd)以及平均脑血流量变化情况,评估2组治疗后效果,并随访1年观察2组复发情况。结果治疗后2组患者左椎动脉、右椎动脉、基底动脉Vs、Vd均较治疗前加快(P均<0.05),平均脑血流量均较治疗前明显升高(P均<0.05),观察组各项指标均明显快于或高于对照组(P均<0.05);治疗后2组中医症状积分及眩晕评分均较治疗前明显降低(P均<0.05),观察组各项评分均明显低于对照组(P均<0.05);观察组治疗总有效率为93.8%(30/32),明显高于对照组的78.1%(25/32),观察组复发率为3.1%(1/32),明显低于对照组的28.1%(9/32),差异均有统计学意义(P均<0.05)。结论应用解痉散瘀汤对椎动脉型颈椎病患者进行治疗,可明显改善椎-基底动脉血流速度和脑血流量,缓解临床症状,疗效确切。
Objective It is to observe the effect of Jiejing Sanyu Decoction on the vertebral-basal artery blood flow velocity and cerebral blood flow in patients with vertebral artery type cervical spondylosis.Methods A total of 64 patients with vertebral artery type cervical spondylosis admitted to Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine from March 2018 to December 2019 were selected and divided into a control group and an observation group according to the random and parallel grouping method,with 32 cases in each group.The control group was treated with flunarizine hydrochloride capsules and nimodipine tablets for routine treatment,and the observation group was treated with Jiejing Sanyu Decoction on the basis of the treatment of the control group.Both groups were treated for 4 consecutive weeks.The changes in the scores of vertigo symptoms,TCM symptom scores,peak systolic blood flow velocity(Vs),diastolic blood flow velocity(Vd)and average cerebral blood flow of left vertebral artery,right vertebral artery,and basilar artery before and after treatment were observed in the two groups,the treatment effects of the two groups after treatment were evaluated,and the recurrence was observed after followed-up for one year in the two groups.Results After treatment,the Vs,Vd and the average cerebral blood flow of the left vertebral artery,right vertebral artery,and basilar artery of patients in the two groups were significantly faster or more than those before treatment(all P<0.05),all the indicators in the observation group were obviously faster or higher than those in the control group(all P<0.05);after treatment,the scores of TCM symptoms and dizziness in the two groups were significantly lower than those before treatment(all P<0.05),and the scores of the observation group were significantly lower than those of the control group(all P<0.05));the total effective rate of treatment in the observation group was 93.8%(30/32),which was significantly higher than 78.1%(25/32)in the control group(P<0.05
作者
康晓乐
鹿洪辉
李德魁
戴爽
马小芳
穆晓红
KANG Xiaole;LU Honghui;LI Dekui;DAI Shuang;MA Xiaofang;MU Xiaohong(Beijing University of Chinese Medicine,Beijing 100029,China;Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《现代中西医结合杂志》
CAS
2021年第22期2418-2422,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
北京中医药大学2020年度科技创新专项(DZMKJCX-2020-041)。
关键词
解痉散瘀汤
椎动脉型颈椎病
椎-基底动脉
脑血流量
Jiejing Sanyu Decoction
cervical spondylopathy of vertebral artery type
vertebral-basilar artery
cerebral blood flow
