摘要
新型冠状病毒(SARS-CoV-2)是否存在抗体依赖性增强(ADE)效应一直备受关注。大阪大学研究团队首次发现在感染SARS-CoV-2后既会产生抵御感染的中和抗体,也会产生增强感染的抗体,在体外证实了SARS-CoV-2导致ADE的可能性,由此更导致大众对疫苗接种的疑虑和担心。本文结合该研究对感染增强抗体在人体中是否导致ADE,以及对疫苗接种和开发的影响进行了剖析和展望。
Antibody-dependent enhancement(ADE)effect of novel coronavirus(SARS-CoV-2)has attracted much attention.The Osaka University research team has for the first time found that infection with SARS-CoV-2 produces both neutralizing antibodies against infection and enhancing antibodies against infection,confirming the possibility that SARS-CoV-2 causes ADE in vitro,thus which further raising public doubts and concerns about vaccination.In this paper,we analyzed and prospected whether the infection-enhancing antibody causes ADE in human body and its impact on vaccination and vaccine development.
作者
何勇
HE Yong(Department of Respiratory and Critical Care Medicine,Army Medical CharacteristicCenter of PLA,Chongqing 400042,China)
出处
《重庆医学》
CAS
2021年第15期2521-2523,2529,共4页
Chongqing medicine
