摘要
目的观察针刺联合疏肝理脾汤治疗慢性乙型肝炎(CHB)的临床疗效及对免疫功能的影响。方法选取102例CHB患者并按照随机数字表法将其分为观察组和对照组,每组51例。对照组采用常规西药治疗,观察组在对照组治疗基础上采用针刺足三里、太冲和阳陵泉联合疏肝理脾汤治疗。观察两组临床疗效并比较治疗前后两组中医证候评分、肝功能、乙肝病毒脱氧核糖核酸(HBV-DNA)定量及免疫功能变化情况。结果观察组临床总有效率明显高于对照组(P<0.05)。治疗后,两组胁肋刺痛、倦怠乏力、脘痞腹胀、恶心嗳气和舌淡齿痕的中医证候评分均低于治疗前(P<0.05),且观察组各项证候评分均低于对照组(P<0.05)。两组治疗后谷丙转氨酶(ALT)、谷草转氨酶(AST)和总胆红素(TBIL)均低于治疗前(P<0.05),两组治疗后白蛋白(ALB)和胆碱酯酶(CHE)均高于治疗前(P<0.05);且观察组治疗后ALT和AST低于对照组(P<0.05),ALB和CHE高于对照组(P<0.05)。两组治疗后CD4^(﹢)、CD4^(﹢)/CD8^(﹢)和γ-干扰素(IFN-γ)水平均高于治疗前(P<0.05),CD8^(﹢)、白介素(IL)-6和IL-8水平均低于治疗前(P<0.05),且观察组治疗后CD4^(﹢)、CD4^(﹢)/CD8^(﹢)和IFN-γ水平高于对照组(P<0.05),CD8^(﹢)、IL-6和IL-8水平均低于对照组(P<0.05)。结论在西药治疗基础上,针刺联合疏肝理脾汤治疗CHB较单纯常规西药治疗能更有效地改善临床症状及肝功能指标,降低病毒定量水平,提高免疫功能。
Objective To observe the clinical efficacy of acupuncture plus Shu Gan Li Pi(soothing the liver and regulating the spleen)decoction in treating chronic hepatitis B(CHB)and its effect on immune function.Method A total of 102 CHB patients were elected and divided into an observation group and a control group using random number table method,with 51 cases in each group.The control group was intervened by conventional Western medication,while the observation group was given additional acupuncture treatment at Zusanli(ST36),Taichong(LR3)and Yanglingquan(GB34)plus Shu Gan Li Pi decoction.Clinical efficacy was observed in each group,and the traditional Chinese medicine(TCM)symptom and sign score,liver function,HBV-DNA quantification and immune function were compared before and after treatment.Result The clinical total effective rate was notably higher in the observation group than in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)symptom and sign scores including stabbing pain in the hypochondrium,fatigue and weakness,nausea and belching,and scalloped pale tongue dropped in both groups(P<0.05),and the scores were lower in the observation group than in the control group(P<0.05).The levels of alanine transaminase(ALT),aspartate transaminase(AST)and total bilirubin(TBIL)declined(P<0.05)and the levels of albumin(ALB)and cholinesterase(CHE)increased(P<0.05)after treatment in both groups;the levels of ALT and AST were lower(P<0.05),and the levels of ALB and CHE were higher(P<0.05)in the observation group than in the control group.After treatment,the levels of CD4^(﹢),CD4^(﹢)/CD8^(﹢)and interferon(IFN)-γincreased(P<0.05),and the levels of CD8^(﹢),interleukin(IL)-6 and IL-8 decreased(P<0.05)in the two groups;the levels of CD4^(﹢),CD4^(﹢)/CD8^(﹢)and IFN-γwere higher(P<0.05),and the levels of CD8^(﹢),IL-6 and IL-8 were lower(P<0.05)in the observation group than in the control group after treatment.Conclusion Compared with conventional Western medication alone,acupuncture plus Shu
作者
王飞
高珊
杨林
WANG Fei;GAO Shan;YANG Lin(Wuhan No.1 Hospital,Wuhan 430022,China)
出处
《上海针灸杂志》
2021年第8期954-958,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
湖北省自然科学基金项目(HBWH201801210)。
关键词
针刺疗法
针药并用
穴
足三里
穴
太冲
穴
阳陵泉
乙型肝炎
慢性
肝功能
免疫功能
Acupuncture therapy
Acupuncture medication combined
Point,Zusanli(ST36)
Point,Taichong(LR3)
Point,Yanglingquan(GB34)
Hepatitis B,Chronic
Liver function
Immune function
