摘要
目的比较甲状腺功能正常的2型糖尿病(type 2 diabetes mellitus,T2DM)与合并桥本甲状腺炎(Hashimoto′s thyroiditis,TH)的T2DM患者一般临床指标,探讨合并TH对T2DM患者25(OH)D水平的影响及其与临床指标的相关性。方法选择142例T2DM患者,依据甲状腺功能结果,分为甲状腺功能正常的T2DM 80例和合并TH的T2DM 62例。比较两组研究对象一般临床资料及25(OH)D水平变化,研究T2DM+TH组25(OH)D水平与甲状腺功能、HbA1c、病程的相关性。结果与单纯T2DM组比较,T2DM+TH组患者病程、TSH、ATG-Ab、TPO-Ab升高,FT 3、FT 4、25(OH)D水平下降,差异有统计学意义(P<0.05)。且该组维生素D(Vit D)营养状态分析显示Vit D不足的发生率下降,缺乏的发生率明显上升,达77.4%。与Vit D不足组比较,Vit D缺乏组患者的TSH、TPO-Ab水平明显升高。T2DM+TH组相关性分析示血清25(OH)D水平与病程、TSH、TPO-Ab之间呈负相关(P<0.05)。结论T2DM合并TH患者,25(OH)D水平明显降低,主要表现为Vit D缺乏。随着TSH及TPO-Ab浓度的增加,25(OH)D水平呈现下降趋势。25(OH)D与T2DM持续时间,TSH、TPO-Ab浓度呈弱的负相关。
Objective To compare the differences in general clinical indicators between type 2 diabetes mellitus(T2DM)patients with normal thyroid function and complicated with Hashimoto′s thyroiditis(TH),to explore the influence of TH on 25(OH)D level in T2DM patients and its correlation with clinical indicators.Methods Totally 142 patients with type 2 diabetes mellitus were selected and divided into two groups according to the results of thyroid function,80 cases of T2DM with normal thyroid function and 60 cases of T2DM with TH.The general clinical data and changes in 25(OH)D levels of the two groups were compared,and the correlation between 25(OH)D levels in the T2DM+TH group and thyroid function,HbA1c,and course of disease was studied.Results Compared with the T2DM group,the course of disease,TSH,ATG-Ab,and TPO-Ab in the T2DM+TH group increased,and the levels of FT 3,FT 4,and 25(OH)D decreased.The difference was statistically significant(P<0.05).And the analysis of Vit D nutritional status in this group showed that the prevalence of Vit D deficiency increased significantly,reaching 77.4%.Compared with the Vit D insufficiency group,the levels of TSH and TPO-Ab in the Vit D deficiency group were significantly higher.Correlation analysis in the T2DM+TH group showed that there was a negative correlation between the serum^(2)5(OH)D level and the course of disease,TSH,and TPO-Ab(P<0.05).Conclusion In patients with T2DM complicated with TH,the level of 25(OH)D is significantly reduced,which is mainly manifested by the lack of Vit D.As the concentration of TSH and TPO-Ab increases,the 25(OH)D level shows a downward trend.25(OH)D has a weak negative correlation with the duration of T2DM,and the concentration of TSH and TPO-Ab.
作者
任旋
武宏霞
张涛
Ren Xuan;Wu Hongxia;Zhang Tao(Department of Endocrinology and Metabolism,Lanzhou University Second Hospital,Gansu 730030,China)
出处
《医学研究杂志》
2021年第8期71-74,共4页
Journal of Medical Research
基金
甘肃省自然科学基金资助项目(1208RJYA044)。
