摘要
抗体是一类重要的生物药物,由于单克隆抗体技术的不断发展,在临床治疗和诊断方面起着举足轻重的作用,但也存在许多局限性,如药代动力学不足,组织可及性差、免疫原性不良和生产成本高,限制了其重复使用。目前,针对目标抗原的合成多肽及多肽的模拟物是抗体的重要替代品。本文主要通过对抗体的结构、抗原与抗体结合的特点及针对抗原特异性靶位点的抗体模拟物的最新进展加以探讨,以期为在抗体应用于临床治疗、基础研究及诊断方面所面临的问题提供理论依据及行之有效的解决措施。
Antibodies are an important class of biopharmaceuticals and they play an important role in clinical treatment and diagnosis because of the continuous development of monoclonal antibody technology.However,there are also many limitations,such as insufficient pharmacokinetics and poor tissue accessibility,dificient immunogenicity and high production costs.Currently,mimics of synthetic polypeptides and polypeptides directed against a target antigen are important substitutes for antibodies.In this paper,the structure of antibodies,the characteristics of antigen-antibody binding and the latest advances in small molecule mimics of peptide antibodies are discussed to provide theoretical basis and effective solutions for the application of antibodies in clinical treatment,basic research and diagnosis.
作者
谭小艳
李翀
顾大勇
何建安
龙军
TAN Xiao-Yan;LI Chong;GU Da-Yong;HE Jian-An;LONG Jun(Department of Laboratory Medicine,Zhujiang Hospital,Southern Medical University,Guangzhou 510280,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2021年第13期1663-1664,F0003,F0004,共4页
Chinese Journal of Immunology
基金
深圳市科技研发基金(JCYJ20160427151920801)资助。
关键词
多肽
抗体模拟物
结构
Polypeptide
Antibody mimetic
Structure
