摘要
目的原发性和继发性肌张力障碍均可以使用苍白球内侧部脑深部电刺激治疗,两种病因导致的疾病可能存在相同的病理基础。运动障碍疾病发生和脑深部电刺激治疗均与局部场电位有关。本文拟探索原发性肌张力障碍和继发性肌张力障碍患者的苍白球内侧部局部场电位特点是否存在差异。方法本文纳入3例继发性肌张力障碍和4例原发性肌张力障碍患者,均表现为全身性肌张力障碍。行苍白球内侧部脑深部电刺激治疗,在电极植入后3~5天内采集局部场电位信号。通过功率谱密度分析和复杂度分析比较两组患者信号是否存在差异。结果两组患者局部场电位功率谱密度连续比较不存在差异,但是在总体频段能量分析中发现原发性肌张力障碍患者3~8 Hz频段能量大于继发性肌张力障碍患者(P=0.0002)。而复杂度分析结果相反,继发性肌张力障碍患者3~8 Hz频段复杂度低于原发性肌张力障碍患者(P=0.0063),继发性肌张力组评分更高。结论局部场电位更多的和症状相关而不是和病因相关,注意要使用复杂度分析补充以避免绝对能量带来的误差。
Objective The globus pallidus internus deep brain stimulation(GPi-DBS) showed good effect in primary and secondary dystonia, hence these two types of dystonia might have the same underlying pathological bsais.Local field potential(LFP) has close relationship with movement disorders and DBS mechanism.However, the local field potential characteristic of Globus Pallidus Internals between primary dystonia and secondary dystonia have not been clarified.Methods Three secondary dystonia and four primary dystonia patients was included in this research.All of them had GPi-DBS.The LFP is recorded 3~5 days after first step surgery.Differences in oscillatory activities were compared by power spectrum and Lempel-Ziv complexity(LZC).Results No significant difference was found in the continuous power spectrum between two groups.However, the 3~8 Hz frequency band power of the primary group is significantly higher than the secondary dystonia group.While the opposite observation was found in LZC analysis, the secondary dystonia had a lower complexity.Conclusion No distinct GPi LFP difference was found between the two groups.The abnormal LFP were related to symptoms rather than specific disease.LZC analysis is an important supplement to those obtained with spectral analyses, which can be introduced to avoid the errors caused by absolute power.
作者
朱冠宇
陈颍川
尹子霄
杜婷婷
张睿俐
王秀
杨岸超
刘焕光
石林
张华
孟凡刚
王守岩
张建国
Zhu Guanyu;Chen Yingchuan;Yin zixiao;无(Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing,100070,China;Department of Functional Neurosurgery,Beijing Neurosurgical Institute,Capital Medical University,Beijing,100070,China;Key Laboratory of Computational Neuroscience arid Brain-Inspired Intelligence(Fudan University),Ministry of Education,200433,China;Beijing Key Laboratory of Neurostimulation,Beijing,100070,China)
出处
《立体定向和功能性神经外科杂志》
2021年第2期65-70,共6页
Chinese Journal of Stereotactic and Functional Neurosurgery
关键词
脑深部电刺激
肌张力障碍
局部场电位
复杂度分析
Deep brain stimulation
Dystonia
Local field potentials
Lempel-Ziv complexity
