摘要
4,6-二氯嘧啶是一种重要的化工中间体。研究了反应温度、溶剂种类、催化剂种类、催化剂用量和反应物投料配比在4,6-二氯嘧啶合成过程中对反应的影响。结果表明,在以邻硝基甲苯为溶剂,苄基三乙基氯化铵为催化剂,且催化剂用量为4,6-二羟基嘧啶质量的2%,n(4,6-二羟基嘧啶)∶n(三光气)=1∶0.8,反应温度为100~110℃的最佳条件下,产品收率可以达到93.4%。
4,6-Dichloropyrimidine is a kind of important chemical intermediates.In this paper,several conditions affecting the synthesis of 4,6-dichloropyrimidine were studied.It was mainly included reaction temperature,type of solvent,type of catalyst,amount of catalyst and proportion of reactants.The results showed that the best solvent was 2-nitrotoluene,the catalyst was benzyltriethylammonium chloride,the optimum amount of the catalyst was 2%of 4,6-dihydroxypyrimidine,the amount of triphosgene was 0.8 times of 4,6-dihydroxypyrimidine,the reaction temperature was 100~110℃,yield of 93.4%.
作者
郭翠红
李娟
杨国忠
李静
刘建俊
GUO Cui-hong;LI Juan;YANG Guo-zhong;LI Jing;LIU Jian-jun(Hebei Chengxin Co.,Ltd.,Shijiazhuang 051130,China;Hebei Province Cyanide Derivatives Technology Innovation Center,Shijiazhuang 051130,China)
出处
《精细与专用化学品》
CAS
2021年第7期36-38,共3页
Fine and Specialty Chemicals
关键词
4
6-二氯嘧啶
反应温度
催化剂
溶剂
收率
4,6-dichloropyrimidine
reaction temperature
Catalyzer
Solvent
yield
