摘要
细胞核是细胞遗传与代谢的控制中心,调控细胞对外界的响应、代谢、生长和分化等细胞活动。在细菌感染宿主细胞过程中,个别细菌来源的效应蛋白能够靶向进入宿主细胞核,影响细胞核内基因的转录、RNA剪切、DNA修复以及染色质重组等生命活动,将这些能够进入细胞核的细菌效应蛋白称之为核调节蛋白。对病原菌分泌的核调节蛋白进入宿主细胞核的方式,以及不同病原菌的核调节蛋白调控宿主细胞的生命过程进行归纳总结,从而为深入探究病原细菌感染宿主细胞的致病机理提供理论基础。
The nucleus is the control center of cell genetics and metabolism,regulating the cell’s responses to the outside environment,metabolism,growth and differentiation and other cellular activities.Many studies have shown that in the process of bacterial infection into host cells,some effector proteins of pathogenic bacteria enter the nucleus of the host cells,affecting gene transcription,RNA splicing,DNA repair,chromatin remodeling,etc.These nucleus-targeting pathogenic effector proteins are called nucleomodulins.This review summarized the means of these nuclear regulatory proteins entering the host nucleus,aftersecreted by pathogenic bacteria.Importantly,the functions of these nucleomodulins regulating the activities of host cells were elucidated.It provides a theoretical basis to further explore the infection and pathogenic mechanisms of intracellular bacteria on host cells.
作者
袁博鑫
吴昊
闫春晓
路娟娥
魏振平
乔建军
阮海华
YUAN Bo-xin;WU Hao;YAN Chun-xiao;LU Juan-e;WEI Zhen-ping;QIAO Jian-jun;RUAN Hai-hua(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;Tianjin University of Commerce,Tianjin 300134,China;Tianjin Key Laboratory of Food Science and Biotechnology,Tianjin 300134,China)
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2021年第7期81-90,共10页
China Biotechnology
基金
国家自然科学基金(31870122)
天津市自然科学基金(18JCYBJC96000)资助项目。
关键词
核调节蛋白
病原细菌
宿主细胞核
Nucleomodulins
Pathogenic bacteria
Host cell nucleus
