摘要
目的:探讨热休克蛋白5(HSPA5)的表达与非小细胞肺癌(NSCLC)生物学特性及预后的关系。方法:检测HSPA5在100例NSCLC癌组织和癌旁组织的表达水平。统计患者的肺癌生物学特性、复发率和死亡率。分析NSCLC癌组织HSPA5表达水平对NSCLC生物学特性及预后的影响。结果:NSCLC癌组织的HSPA5阳性表达率、HSPA5蛋白和mRNA表达水平均高于其癌旁组织(P<0.05)。NSCLC癌组织HSPA5表达水平随着临床分期的升高而升高,随着分化程度的升高而降低(P<0.05);复发患者癌组织HSPA5表达水平高于未复发患者(P<0.05);死亡患者癌组织HSPA5表达水平高于存活患者(P<0.05)。NSCLC癌组织的HSPA5表达可明显影响NSCLC生物学特性及预后情况(P<0.05)。结论:HSPA5在癌组织中高表达且与NSCLC生物学特性及预后相关。
Objective:To investigate the relationship between the expression of heat shock protein 5(HSPA5)and the biological characteristics and prognosis of non-small cell lung cancer(NSCLC).Methods:The expression level of HSPA5 in 100 NSCLC carcinomas and paracancerous tissues was detected.The biological characteristics,recurrence rate and mortality of lung cancer were analyzed.To analyze the influence of HSPA5 expression level on the biological characteristics and prognosis of NSCLC.Results:The positive expression rate,protein and mRNA expression levels of HSPA5 in NSCLC cancer tissues were higher than those in adjacent tissues(P<0.05).The expression level of HSPA5 in NSCLC cancer tissues increased with the clinical stage,but decreased with the differentiation degree(P<0.05).The expression level of HSPA5 in cancer tissues of patients with recurrence was higher than that of patients without recurrence(P<0.05).The expression level of HSPA5 in cancer tissues of dead patients was higher than that of alive patients(P<0.05).The expression of HSPA5 in NSCLC cancer tissue significantly affected the biological characteristics and prognosis of NSCLC(P<0.05).Conclusion:HSPA5 is highly expressed in cancer tissues and is related to the biological characteristics and prognosis of NSCLC.
作者
钟斌
郑婕
廖信辉
文慧兰
陈兴翔
刘惟优
ZHONG Bin;ZHENG Jie;LIAO Xinhui;WEN Huilan;CHEN Xingxiang;LIU Weiyou(The First Affiliated Hospital of Gannan Medical College,Ganzhou Jiangxi 341000,China.)
出处
《药品评价》
CAS
2021年第12期744-746,共3页
Drug Evaluation
基金
赣州市2020年指导性科技计划项目(GZ2020ZSF026)。
关键词
癌
非小细胞肺
热休克蛋白5
生物学特性
预后
Carcinoma,non-small-cell lung
Heat shock protein 5
Biological characteristics
Prognosis
