摘要
大黄酚是从中药中提取出来的蒽醌类有效单体之一,以游离苷元形式存在于大黄、何首乌、虎杖、决明子、半夏等。研究发现,大黄酚在神经保护、抗氧化、抗癌、抗炎、抗菌及抗病毒、促进脂肪代谢等方面都表现出良好的药理活性。虽然,人们对大黄酚的药理活性研究较多,但是对它的整体概述相对较少。该文对大黄酚药理作用进行全面综述,为进一步研究和临床应用提供有价值的参考。
Chrysophanol is one of the effective monomers of anthraquinones that extracted from traditional Chinese medicine.It exists in the form of free aglycon in rhubarb,fleeceflower root,polygonum cuspidatum,cassia,pinellia,etc.Studies have found that chrysophanol has good pharmacological activities in neuroprotection,anti-oxidation,anti-cancer,anti-inflammatory,antibacterial and anti-virus,and promotion of fat metabolism.Although there are many studies on the pharmacological activity of chrysophanol,the overall review of it is relatively few.This article provides a comprehensive review of the pharmacological effects of chrysophanol,and provides valuable references for further research and clinical applications.
作者
袁鑫茹
张丹参
YUAN Xin-ru;ZHANG Dan-shen(Hebei University of Science and Technology,Shijiazhuang,050000,China)
出处
《神经药理学报》
2020年第6期34-40,共7页
Acta Neuropharmacologica
基金
河北省重点研发计划项目生物医药专项(No.20372509D)
河北省自然科学基金(No.H2020208032)
河北省高等学校科学技术研究项目(No.ZD2020117)
河北省中医药管理局中医药科研计划项目(No.2020268)
中央财政公共卫生专项“中药资源普查项目”(No.Z135080000022)。
关键词
大黄酚
神经保护
抗氧化
抗癌
抗炎
Chrysophanol
neuroprotection
antioxidant
anti-cancer
anti-inflammatory
