摘要
在糖尿病状态下,失调的自噬可能导致多个脏器的病变。mTOR介导的自噬参与糖尿病并发症及合并疾病的调控机制,如糖尿病肾病、非酒精性脂肪肝、糖尿病心脏病、糖尿病性视网膜病变、糖尿病周围神经病变等。对糖尿病自噬机制的研究将有助于发现新的治疗靶点,更好的预防和治疗糖尿病并发症。
In the state of diabetes,dysfunctional autophagy may lead to pathological changes of multiple organs.The mTOR-mediated autophagy is involved in the regulation of diabetic complications and concomitant diseases,such as diabetic nephropathy,non-alcoholic fatty liver,diabetic heart disease,diabetic retinopathy,diabetic peripheral neuropathy and so on.The study on the mechanism of diabetic autophagy will help to find new therapeutic targets and better methods to prevent and treat diabetic complications.
作者
钱子冰
刘静
曾佩芸
张琦
QIAN Zi-bing;LIU Jing;ZENG Pei-yun;ZHANG Qi(Gansu University of Traditional Chinese Medicine, Lanzhou 730000;Department of Endocrinology, Gansu Provincial People's Hospital,Lanzhou 730000,China)
出处
《基础医学与临床》
2021年第8期1200-1204,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(81760151)。
