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拉莫三嗪常规剂量或加量治疗成人癫痫的临床效果及安全性

Clinical Effect and Safety of Lamotrigine with Routine Dose or Increased Dose in the Treatment of Adult Epilepsy
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摘要 目的:探究与分析拉莫三嗪常规剂量或加量治疗成人癫痫的临床效果及不良反应。方法:选取本院2018年5月-2020年5月收治的80例成人癫痫患者。采用随机数字表法分为对照组和观察组,各40例。对照组给予常规拉莫三嗪常规治疗,观察组给予拉莫三嗪加量治疗。对比两组临床疗效、治疗后拉莫三嗪血药浓度、治疗前后发作频率及不良反应。结果:两组治疗总有效率比较差异无统计学意义(P>0.05)。观察组治疗后血药浓度高于对照组,差异有统计学意义(P<0.05)。治疗后,两组癫痫发作频率较治疗前降低,差异有统计学意义(P<0.05);治疗后两组癫痫发作频率比较差异无统计学意义(P>0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:拉莫三嗪常规剂量或者加量治疗成人癫痫的临床效果无明显差异,均较为良好,同时均明显降低了癫痫发作频率,二者不良反应均较轻,安全性较高。 Objective:To explore and analyze the clinical effect and adverse reactions of Lamotrigine with routine dose or increased dose in the treatment of adult epilepsy.Method:A total of 80 adult patients with epilepsy admitted to our hospital from May 2018 to May 2020 were selected and divided into the control group and the observation group by random number table method,with 40 cases in each group.The control group was given Lamotrigine conventional treatment,the observation group was given Lamotrigine with increased dose treatment.Compared the clinical curative effect,blood concentration of Lamotrigine after treatment,seizure frequency before and after treatment and adverse reactions of the two groups.Result:There was no significant difference in total effective rate between the two groups (P>0.05).After treatment,the blood concentration of the observation group was higher than that of the control group,and the difference was statistically significant (P<0.05).After treatment,the frequency of seizures in the two groups was lower than that that before treatment,and the difference was statistically significant (P<0.05);there was no significant difference in the frequency of seizures between the two groups after treatment (P>0.05).There was no significant difference in incidence of adverse reactions between the two groups (P>0.05).Conclusion:There is no significant difference in clinical efficacy of Lamotrigine in adult epilepsy patients treated with routine dose or increased dose,both of which are relatively good,and both of which significantly reduce the frequency of epilepsy seizures,and both of which have relatively mild adverse reactions and high safety.
作者 丁怀然 DING Huairan(Xintai People’s Hospital,Xintai 271200,China)
机构地区 新泰市人民医院
出处 《中外医学研究》 2021年第18期62-64,共3页 CHINESE AND FOREIGN MEDICAL RESEARCH
关键词 拉莫三嗪 加量治疗 成人癫痫 疗效 安全性 Lamotrigine Additional treatment Adult epilepsy Curative effect Security
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