摘要
目的:观察不同频率电针对全麻腹腔镜下结直肠癌根治术后患者的影响。方法:采用随机数字表法将120例择期行腹腔镜下结直肠癌根治术的患者分为A、B、C组,每组40例。A组行全凭静脉麻醉,B、C组在全身麻醉前先接受电针麻醉诱导30 min,取穴三阴交、足三里、内关、百会,连续给予刺激直至术毕。B组采用2 Hz连续波型,C组采用100 Hz连续波型,A组仅在穴位处粘贴电极片,不予电刺激。观察并比较3组患者胃肠功能、应激反应、细胞因子与免疫功能指标变化情况。结果:A组患者肠鸣音恢复时间、首次排便时间均长于B、C组(P<0.05),首次排气时间长于C组(P<0.05),B组与C组比较,差异无统计学意义(P>0.05);3组组内不同时间点血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、胃动素(MTL)水平均有差异(P<0.05),3组患者同时间点IL-2、IL-6水平有差异(P<0.05),分组与时间对IL-2、IL-6水平的影响存在交互作用(P<0.05);3组患者组内不同时间点血清C反应蛋白(CRP)、淀粉样蛋白(SAA)水平均有差异(P<0.05),3组患者同时间点CRP、SAA水平均有差异(P<0.05),分组与时间对CRP、SAA水平的影响存在交互作用(P<0.05);3组患者组内不同时间点的CD4+水平均有差异(P<0.05),3组患者同时间点CD4+水平均有差异(P<0.05),分组与时间对CD4+水平的影响存在交互作用(P<0.05)。结论:电针刺激能够有效改善腹腔镜结直肠癌患者术后胃肠功能,减轻应激反应与免疫抑制。100 Hz连续波型电针刺激效果优于2 Hz连续波型。
Objective:To observe the effect of electroacupuncture of different frequency on patients with laparoscopic radical resection of colorectal cancer with general anesthesia.Methods:Totally 120 patients with laparoscopic radical resection of colorectal cancer were divided into group A,B and C,with 40 patients in each group,according to random number table method.Group A received endotracheal general anesthesia,while group B and C received induction of electroacupuncture anesthesia for 30 min before general anesthesia,and Sanyinjiao(SP6),Zusanli(ST36),Neiguan(PC6)and Baihui(GV20)were selected.Group B adopted 2 Hz continuous wave type while group C adopted 100 Hz continuous wave type.The electroacupuncture was connected with continuous stimulation until the end of the operation.Group A only pasted electrode at the acupoints without electroacupuncture stimulation.The changes of gastrointestinal function,stress response,cytokines and immune function were observed and compared among the three groups.Results:Group A showed longer recovery of bowel sounds and time of first defecation than group B and C(P<0.05),as well as longer time of first exhaust than group C(P<0.05).There was no significant difference between group B and C(P>0.05).There was significant difference in levels of interleukin-2(IL-2),interleukin-6(IL-6)and motilin(MTL)among the three groups at different time points(P<0.05),and there was significant difference in levels of IL-2 and IL-6 among the three groups at the same time point(P<0.05).There was interaction between grouping factors and time on the levels of IL-2 and IL-6(P<0.05).There was significant difference in levels of serum C-reactive protein(CRP)and amyloid protein(SAA)in the three groups at different time(P<0.05),and there was significant difference in levels of CRP and SAA among the three groups at the same time point(P<0.05).There was interaction between grouping factors and time on levels of CRP and SAA(P<0.05).There was significant difference in CD4 levels among the three groups at different t
作者
李文霞
赵静霞
冉德伟
LI Wen-xia;ZHAO Jing-xia;RAN De-wei(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)
出处
《中医药导报》
2021年第7期93-96,99,共5页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
北京市科研培育计划项目(PZ2018038)。
关键词
结直肠癌
腹腔镜
全身麻醉
频率
电针
colorectal cancer
laparoscope
general anesthesia
frequency
electroacupuncture
