摘要
目的探讨胃癌患者行手术治疗后早期应用肠道微生态治疗的短期疗效。方法回顾性分析2020年6月1日至2021年5月31日在树兰(杭州)医院胃肠外科行手术治疗的早中期胃癌患者96例,其中观察组48例患者在术后早期使用肠内营养支持治疗的基础上加用肠道微生态制剂;对照组48例患者在术后早期单纯使用肠内营养支持治疗。分别在术前以及术后第7天检测所有被选患者的血清总蛋白、白蛋白、前白蛋白等营养相关指标和CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)等免疫相关指标,记录患者术后肛门首次排气时间及感染性并发症发生情况等临床指标。结果两组患者术前血清总蛋白、白蛋白、前白蛋白等营养相关指标及CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)等免疫相关指标比较差异无统计学意义(P>0.05);术后7 d,观察组患者上述指标均明显高于对照组(P<0.05)。观察组患者术后肛门恢复排气时间更快(P<0.05),两组患者术后感染性并发症发生率差异无统计学意义(P>0.05)。结论胃癌患者术后早期应用肠道微生态制剂,可明显改善术后的营养状况和免疫功能,促进肠道功能恢复,且不会增加并发症的发生率。
Objective To study the short-term effect of early application of intestinal microecological therapy after gastric cancer surgery.Methods A retrospective analysis was made on 96 patients with early and middle stage gastric cancer who underwent surgical treatment in the department of gastrointestinal surgery of Shulan(Hangzhou)Hospital from June 1,2020 to May 31,2021.Among them,48 patients in the observation group were given enteral nutrition support treatment in the early stage after operation and intestinal microecological preparation,while the control group of 48 patients in the early postoperative were given enteral nutrition support.The serum total protein,albumin,prealbumin and other nutrition related indexes and immune related indexes such as CD4^(+),CD8^(+),CD4^(+)/CD8^(+) were detected before and 7 days after operation.The clinical indexes such as the time of first anal exhaust and the incidence of infectious complications were recorded.Results There was no significant difference between the two groups in preoperative serum total protein,albumin,prealbumin and immune related indexes such as CD4^(+),CD8^(+),CD4^(+)/CD8^(+)(P>0.05).7 days after operation,the above indexes in the observation group were significantly higher than those in the control group(all P<0.05).The anal exhaust recovery time of observation group was faster(P<0.05);There was no significant difference in the incidence of postoperative infectious complications between the two groups(P>0.05).Conclusions Early application of intestinal microecological agents in patients with gastric-cancer after operation can significantly improve the nutritional status and immune function,promote the recovery of intestinal function,and will not increase the incidence of complications.
作者
吴芳
杨红梅
林文发
叶再元
吴松阳
薄志远
陈振光
罗瑶
Wu Fang;Yang Hongmei;Lin Wenfa;Ye Zaiyuan;Wu Songyang;Bo Zhiyuan;Chen Zhenguang;Luo Yao(Department of Gastrointestinal Surgery,Shulan(Hangzhou)Hospital,Hangzhou 310000,China;Graduate School of Zhejiang Chinese Medical University,Hangzhou 330022,China)
出处
《中国医师杂志》
CAS
2021年第7期974-977,共4页
Journal of Chinese Physician
关键词
胃肿瘤
肠道微生态
肠内营养
Stomach neoplasms
Intestinal microecology
Enteral nutrition
