摘要
目的:观察复苏合剂联合注射用甲泼尼龙治疗中重度急性呼吸窘迫综合征(ARDS)的临床疗效及对患者血气指标、炎症因子的影响。方法:选取70例中重度ARDS患者,按随机数字表法分为观察组和对照组各35例。对照组给予注射用甲泼尼龙治疗,观察组在对照组基础上加用复苏合剂治疗。比较2组临床疗效;比较2组治疗前后急性肺损伤(Murray)评分、急性生理学与慢性健康状况评分系统(APACHEⅡ)评分、血气指标、血清炎症因子水平;记录2组不良反应。结果:观察组总有效率为88.57%,高于对照组的65.71%(P<0.05)。治疗后,2组Murray、APACHEⅡ评分均较治疗前降低(P<0.05),观察组Murray、APACHEⅡ评分均低于对照组(P<0.05)。治疗后,2组动脉血氧分压(PaO2)、动脉血氧饱和度(SaO2)及氧合指数(PaO2/FiO2)均较治疗前升高(P<0.05),血清白细胞介素-1β(IL-1β)、白细胞介素-10 (IL-10)、白细胞介素-6 (IL-6)水平均较治疗前降低(P<0.05);观察组PaO2、SaO2及PaO2/FiO2均高于对照组(P<0.05),血清IL-1β、IL-10、IL-6水平均低于对照组(P<0.05)。2组治疗过程中均未出现与药物相关的严重不良反应。结论:复苏合剂联合注射用甲泼尼龙治疗中重度ARDS,能明显改善患者的临床症状、血气指标,减轻机体炎症反应,且安全性较好。
Objective: To observe the clinical effect of Fusu mixture combined with methylprednisolone injection in the treatment of moderate to severe acute respiratory distress syndrome(ARDS) and its effect on blood gas index and inflammatory factors. Methods:A total of 70 cases of patients with moderate to severe ARDS were selected and divided into the observation group and the control group according to the random number table method, 35 cases in each group. The control group was treated with methylprednisolone injection,and the observation group was additionally treated with Fusu mixture based on the treatment of the control group. The clinical effect in the two groups were compared. Before and after treatment,the scores of Murray’s Acute Lung Injury Score and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHEⅡ),the blood gas indexes and the levels of inflammatory factors in serum in the two groups were compared. The adverse reactions in the two groups were compared. Results:The total effective rate was 88.57% in the observation group,higher than that of 65.71% in the control group(P<0.05). After treatment,the scores of Murray and APACHEⅡ in the two groups were decreased when compared with those before treatment(P<0.05), and the scores of Murray and APACHE Ⅱ in the observation group were lower than those in the control group(P<0.05). After treatment, the levels of partial pressure of oxygen(PaO2),oxygen saturation(SaO2) and oxygenation index(PaO2/FiO2) in the two groups were increased when compared with those before treatment(P<0.05),and the levels of interleukin-1β(IL-1β),interleukin-10(IL-10) and interleukin-6(IL-6)in serum in the two groups were decreased(P<0.05);the levels of PaO2,SaO2 and PaO2/FiO2 in the observation group were higher than those in the control group(P<0.05),and the levels of IL-1β,IL-10 and IL-6 in serum were lower than those in the control group(P<0.05). During treatment, there was no severe adverse reaction related to drugs. Conclusion: Fusu mixture combined with methylprednisol
出处
《新中医》
CAS
2021年第13期61-64,共4页
New Chinese Medicine
关键词
急性呼吸窘迫综合征
复苏合剂
甲泼尼龙
血气分析
炎症因子
Acute respiratory distress syndrome
Fusu mixture
Methylprednisolone
Blood gas analysis
Inflammatory factors
