摘要
目的:探讨富含“食药同源”食材提取物的米稀和饼干(基于茯苓-山药复配提取物开发的米稀和基于猴头菇提取物开发的饼干)对乙醇致大鼠胃黏膜损伤的改善作用。方法:口服给予大鼠无水乙醇,建立急性胃黏膜损伤模型,随机分为正常组、模型组、阳性组、茯苓-山药复配提取物低、中、高剂量组、米稀低、中、高剂量组、猴头菇提取物低、中、高剂量组、饼干低、中、高剂量组。在此基础上,探究4种受试物对乙醇致大鼠胃黏膜损伤的改善作用(观测大鼠生长状况和胃黏膜损伤状况)。结果:与正常组相比,模型组大鼠胃部可见明显出血条带及大量出血点,胃黏膜腺体结构紊乱,上皮细胞脱落及黏膜严重充血,胃黏膜损伤指数也极显著增加。与模型组相比,4种受试物各剂量组大鼠胃部出血条带和出血点显著减少,胃黏膜损伤明显减轻。结论:4种受试物对乙醇致大鼠急性胃黏膜损伤均有较好地预防保护作用,且茯苓-山药复配提取物及其米稀的效果优于猴头菇提取物及其饼干。本研究结果可为改善胃、肠道功能健康产品提供数据支持。
Objective:The effects of rice paste and biscuit rich in Chinese medicine homologous food extract(rice paste rich in Poria cocos-yam extract,and biscuit rich in Hericium erinaceus extract)on ethanol-induced gastric mucosal injury in rats was investigated in this study.Methods:Acute gastric mucosal injury model was established by orally administering absolute ethanol to rats.Rats were randomly divided into normal group,model group,positive group,three Poria cocos-yam extract treatment groups(low,medium,high dose),three rice paste treatment groups(low,medium,high dose),three Hericium erinaceus extract treatment groups(low,medium,high dose),and three biscuit treatment groups(low,medium,high dose).On this basis,the effects of four test substances on ethanol-induced gastric mucosal injury in rats were further explored(observation of rat growth and gastric mucosal injury).Results:Compared with the normal group,the model group showed obvious bleeding bands,a large number of bleeding locations,gastric mucosal glandular structure disorder,epithelial cell shedding and severe congestion,and significantly increased gastric mucosal injury index.Compared with the model group,the gastric bleeding bands and bleeding locations of rats in each dose group of the four kinds of treatment were significantly reduced.In addition,the gastric mucosal damage for rats was also significantly reduced.Conclusion:The four kinds of treatment have better preventive effects on ethanol-induced acute gastric mucosal injury in rats.Meanwhile,the effect of Poria cocos-yam extract and the rice paste in each dose was better than Hericium erinaceus extract and the biscuit.The results in this study can provide data support for the development of health products for improving gastrointestinal function.
作者
潘猛
徐德昌
孙永敢
胡婕伦
聂少平
钟虹光
尧梅香
谢明勇
Pan Meng;Xu Dechang;Sun Yonggan;Hu Jielun;Nie Shaoping;Zhong Hongguang;Yao Meixiang;Xie Mingyong(State Key Laboratory of Food Science and Technology,Nanchang University,China-Canada Food Science and Technology Joint Laboratory(Nanchang),Nanchang 330047;Jiangxi Jiangzhong Shiliao Science and Technology Co.,Ltd.,Jiujiang 330000,Jiangxi)
出处
《中国食品学报》
EI
CAS
CSCD
北大核心
2021年第7期115-122,共8页
Journal of Chinese Institute Of Food Science and Technology
基金
国家重点研发课题(2017YFC1600405)
江西省重大研发专项(20165ABC28004)。
关键词
“食药同源”食材
茯苓
山药
猴头菇
米稀
饼干
胃黏膜损伤
Chinese medicine homologous food
Poria cocos
yam
Hericium erinaceus
rice paste
biscuit
gastric mucosal injury
