摘要
目的探讨慢性肾病合并高血压(HCKD)患者血清心钠肽(ANP)、心肌肌钙蛋白(cTnI)表达水平及与心律失常(CA)的相关性研究。方法选取2017年6月—2019年6月湖北省监利市第五人民医院收治的136例HCKD患者作为研究对象,根据是否发生心律失常将其分为CA组(发生心律失常,92例)及无CA组(未发生心律失常,44例),比较不同亚组间血清ANP、cTnI水平。比较CA组和无CA组心脏变异率(HRV)指标间的关系。分析血清ANP、cTnI水平与HRV指标间的相关性。结果随着LOWNS分级的不断增大,血清ANP、cTnI表达水平逐渐升高,差异有统计学意义(P<0.05);CA组患者SDNN、SDANN、rMSSD、pNN50水平均低于无CA组,差异有统计学意义(P<0.05);CA组ANP水平与SDNN、SDANN、rMSSD、pNN50水平呈负相关,差异有统计学意义(r=-0.679,-0.603,-0.472,-0.738,P<0.05)。结论HCKD患者血清ANP、cTnI水平可能与发生CA的严重程度有关,LOWNS分级越高,CA的严重程度越高。血清ANP、cTnI水平的检测,对CA的评估具有一定的价值。
Objective To investigate the expression levels of serum atrial natriuretic peptide(ANP)and cardiac troponin(cTnI)in patients with hypertensive with chronic kidney disease(HCKD)and their cardiac arrhythmia(CA).Methods A total of 136 patients with HCKD admitted to the Fifth People′s Hospital of Jianli City,Hubei Province from June 2017 to June 2019 were selected as the research objects,according to whether there was arrhythmia,they were divided into CA group(92 cases with arrhythmia)and non CA group(44 cases without arrhythmia),serum ANP and cTnI levels were compared among different subgroups.The relationship between heart rate variability(HRV)in CA group and non CA group was compared.The correlations between serum ANP,cTnI and HRV were analyzed.Results With the increase of lowns grade,the expression levels of ANP and cTnI in serum increased gradually and the difference was statistically significant(P<0.05).The levels of SDNN,SDANN,rMSSD and pNN50 in CA group were lower than those in CA group the difference was statistically significant(P<0.05).The ANP level was negatively correlated with SDNN,SDANN,rMSSD,pNN50 level in CA group the difference was statistically significant(r=-0.679,-0.603,-0.472,-0.738,P<0.05).Conclusion Serum ANP and cTnI levels may be related to the severity of Ca in patients with HCKD,the higher the LOWNS classification,the higher the severity of CA.The detection of serum ANP and cTnI levels has certain value for the evaluation of CA.
作者
黄丽
HUANG Li(Department of Laboratory,the Fifth People′s Hospital of Jianli City,Hubei Province,Jianli433300,China)
出处
《中国当代医药》
CAS
2021年第21期178-181,共4页
China Modern Medicine
关键词
慢性肾病合并高血压
心钠肽
心肌肌钙蛋白
心律失常
Hypertensive with chronic kidney disease
Atrial natriuretic peptide
Cardiac troponin
Cardiac arrhythmia
