摘要
EB(Epstein-Barr)病毒普遍性感染人类并引发多种病毒相关性癌症,其中鼻咽癌与EB病毒感染相关性最高,并在我国广东等地区发病率极高,是我国重点防治的十大恶性肿瘤之一。截至目前,没有任何一款上市可接种的EB病毒防治性疫苗,针对EB病毒相关疾病的免疫治疗手段在临床试验中也收效甚微。近年来,纳米颗粒基因改造技术的飞速发展为EB病毒的防治带来了新希望。新型功能化纳米颗粒疫苗载体具有高稳定性、高生物兼容性、高安全性及多功能联合等优势,已被各国团队用于EB病毒预防及治疗的研究中,并取得了一定的进展。该文介绍并评述了国内外研究小组利用功能化外泌体纳米颗粒、类病毒颗粒、铁蛋白自组装纳米颗粒以及一些其他类型的纳米颗粒所开展的EB病毒防治疫苗的研究进展,并对功能化纳米颗粒在EB病毒疫苗临床转化过程中可能面临的难题和挑战进行了展望。
Epstein-Barr virus causes a ubiquitous infection in adults worldwide.It is also a oncogenic virus that is associated with many cancers,including nasopharyngeal carcinoma which is one of the predominant tumor in South China.However,so far,a vaccine against Epstein-Barr virus was not yet available in the world and there is no effective immunotherapy against those Epstein-Barr virus associated carcinomas.With the advantages of high stability,biocompatibility,low toxicity and multifunctional regions,the next generation nanoparticles has been successfully applied in the research of Epstein-Barr virus vaccines.In this article,the recent advances of nanoparticles,including exosomes,virus-like particles,self-assembling ferritin nanoparticles and other nanoparticles using for prevention and against of Epstein-Barr virus infections have been reviewed and further discussed.Finally,the opportunities and challenges faced by engineered nanoparticles in the clinical application are prospected.
作者
黄建东
黄琨
HUANG Jiandong;HUANG Kun(Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China)
出处
《集成技术》
2021年第4期67-77,共11页
Journal of Integration Technology
基金
深圳市科技创新委员会项目(KQTD2015033117210153,JCYJ20180302145817753)。
关键词
EB病毒
纳米颗粒
外泌体
类病毒颗粒
铁蛋白自组装纳米颗粒
Epstein-Barr virus
nanoparticle
exosome
virus-like particle
self-assembling ferritin nanoparticle
