摘要
目的探讨慢性阻塞性肺疾病(chronic obstruotive pilmonary COPD)患者血气分析指标,呼出气一氧化氮(fractional exhaled nitric FeNO),外周血嗜酸性粒细胞占比(eosinophil EOS%)水平变化与COPD评估测试(CAT)评分的相关性。方法选取2017年2月~2019年10月遂宁市中心医院收治的急性加重期COPD(AECOPD)患者127例(A组),COPD稳定期患者124例(B组),健康志愿者120例(健康组)。对比A组与B组CAT评分;对比三组及A组,B组不同GOLD分级患者FeNO,EOS%与血气分析指标;分析血气分析指标以及FeNO,EOS%与CAT评分的相关性。结果A组CAT评分高于B组(25.63±4.50分vs 16.39±3.04分),差异有统计学意义(t=16.938,P<0.001)。A组FeNO,EOS%,PaO_(2),PaCO_(2),氧合指数和pH值分别为45.84±8.10ppb,(8.15±0.62)%,61.05±6.82mmHg,60.20±6.71mmHg,278.52±24.08和7.28±0.05;B组分别为32.58±6.02ppb,(4.80±0.48)%,74.55±7.15mmHg,48.50±6.10mmHg,374.69±35.89和7.35±0.05;C组分别为26.25±3.06ppb,(2.51±0.32)%,94.56±9.13mmHg,40.01±6.02mmHg,452.46±46.93和7.42±0.06,差异均有统计学意义(F=96.752,49.803,36.955,37.982,125.406和52.844,均P<0.001)。A组FeNO,EOS%,PaCO_(2)均高于B组和健康组,且B组均高于健康组;A组PaO_(2),氧合指数,pH值均低于B组和健康组,且B组均低于健康组;A组,B组患者CAT评分,FeNO,EOS%,PaCO_(2)均随GOLD分级增加而增加(A组:r=0.812,0.835,0.796和0.743,P=0.007,0.003,0.012和<0.001;B组:r=0.759,0.762,0.731和0.702,P=0.015,0.009,0.023和0.004),而PaO_(2),氧合指数,pH值均随GOLD分级增加而降低(A组:r=-0.832,-0.845和-0.877,P=0.004,0.009和<0.001;B组:r=-0.796,-0.811和-0.836,P=0.005,0.017和0.009);A组,B组中PaO_(2),氧合指数,pH值与CAT评分均呈负相关(A组:r=-0.841,-0.791和-0.763,均P<0.05;B组:r=-0.806,-0.744和-0.722,均P<0.05);PaCO_(2),FeNO,EOS%与CAT评分均呈正相关(A组:r=0.836,0.812和0.704,均P<0.05;B组:r=0.820,0.836和0.758,均P<0.05)。结论AECOPD和COPD患者FeNO,EOS%,PaCO_(2)均偏高,而PaO_(2),氧合指数和pH值均偏低,且与�
Objective To investigate the correlation between the changes of blood gas analysis indexes,fractional exhaled nitric oxide(FeNO),eosinophil percentage(EOS%)in peripheral blood and COPD assessment test(CAT)score in patients with chronic obstructive pulmonary disease(COPD).Methods From February 2017 to October 2019,127 patients with AECOPD(A group),124 patients with stable COPD(B group)and 120 healthy volunteers(health group)were enrolled in Suining Central Hospital.The CAT scores of group A and group B were compared.The FeNO,EOS%and blood gas analysis indexes of three groups and different GOLD grades of group A and group B were compared.The correlations between blood gas analysis indexes,FeNO,EOS%and CAT score were analyzed.Results The CAT score of group A was higher than that of group B 25.63±4.50 scores vs 16.39±3.04 scores,the difference was statistically significant(t=16.938,P<0.001).The FeNO,EOS%,PaO_(2),PaCO_(2),oxygenation index and pH value in group A were 45.84±8.10 ppb,(8.15±0.62)%,61.05±6.82 mmHg,60.20±6.71 mmHg,278.52±24.08 and 7.28±0.05 respectively,which were 32.58±6.02 ppb,(4.80±0.48)%,74.55±7.15 mmHg,48.50±6.10 mmHg,374.69±35.89 and 7.35±0.05 in group B,and those were 26.25±3.06 ppb,(2.51±0.32)%,94.56±9.13 mmHg,40.01±6.02 mmHg,452.46±46.93 and 7.42±0.06 in group C,with statistically significant differences(F=96.752,49.803,36.955,37.982,125.406 and 52.844,all P<0.001).In group A,FeNO,EOS and PaCO_(2) were higher than those in group B and healthy group,which in group B were higher than those in healthy group.PaO_(2),oxygenation index and pH value of group A were lower than those of group B and healthy group,which in group B were lower than those of healthy group.CAT scores,FeNO,EOS%and PaCO_(2) in group A and group B increased with the increase of GOLD grade in group A and B(group A:r=0.812,0.835,0.796,0.743,P=0.007,0.003,0.012,<0.001;group B:r=0.759,0.762,0.731,0.702,P=0.015,0.009,0.023,0.004),while PaO_(2),oxygenation index and pH value decreased with the increase of GOLD grade(
作者
王述红
邱容
罗晓斌
赵勇
罗文
杜发旺
李丽
罗丽
赵界
WANG Shu-hong;QIU Rong;LUO Xiao-bin;ZHAO Yong;LUO Wen;DU Fa-wang;LI Li;LUO Li;ZHAO Jie(the Second Ward in Department of Respiratory and Critical Care Medicine,Suining Central Hospital,Sichuan Suining 629000,China)
出处
《现代检验医学杂志》
CAS
2021年第4期156-161,共6页
Journal of Modern Laboratory Medicine
基金
四川省卫生和计划生育委员会科研立项(NO.17pg037)呼出气NO测定在慢性阻塞性肺疾病频繁加重表型的作用研究。
关键词
慢性阻塞性肺疾病
血气分析
呼出气一氧化氮
嗜酸性粒细胞
慢性阻塞性肺病评估测试
chronic obstructive pulmonary disease
blood gas analysis
exhaled nitric oxide
eosinophils
chronic obstructive pulmonary disease assessment test
