摘要
目的:比较头孢替安与头孢呋辛治疗泌尿系统感染的临床疗效、不良反应发生率及血清白介素-4(IL-4)、白介素-6(IL-6)、白介素-8(IL-8)浓度变化。方法:2018年1月-2020年6月收治泌尿系统感染患者130例,随机分为两组,各65例。对照组给予头孢呋辛治疗,观察组给予头孢替安治疗,比较两组治疗效果。结果:观察组治愈率显著高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组治疗后IL-4、IL-6、IL-8水平均显著低于对照组,差异有统计学意义(P<0.05)。结论:头孢替安治疗泌尿系统感染的临床疗效优于头孢呋辛,可有效降低炎症因子水平,且安全性好。
Objective:To compare the clinical efficacy and incidence of adverse reactions of cefotiam and cefuroxime in the treatment of urinary tract infection,and the changes of serum IL-4,IL-6 and IL-8 levels before and after treatment.Methods:From January 2018 to June 2020,130 cases of patients with urinary system infection were enrolled,they were randomly divided into two groups with 65 cases in each group.The control group was given cefuroxime.The observation group was treated with cefotiam.The therapeutic effects between the two groups was compared.Results:The cure rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions between the two groups was compared,the difference was not statistically significant(P>0.05).After treatment,the IL-4,IL-6 and IL-8 levels in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The clinical effect of cefotiam is better than cefuroxime,which can effectively reduce inflammatory factor level and has high safety.
作者
朱东芳
Zhu Dongfang(The Maternal and Child Care Service Hospital of Changping District,Beijing City,Beijing 102200)
出处
《中国社区医师》
2021年第21期74-75,共2页
Chinese Community Doctors
关键词
头孢替安
头孢呋辛
泌尿系统感染
炎症反应
Cefotiam
Cefuroxime
Urinary system infection
Inflammatory response
