摘要
目的研究甲状旁腺激素辅助治疗老年骨质疏松性股骨转子间骨折术后愈合的临床效果。方法选取我院骨科2019年1~12月采用股骨近端防旋髓内钉(PFNA)手术方式治疗的老年骨质疏松性股骨转子间骨折病人60例,并随机分成2组,每组30例。其中,对照组进行术后骨质疏松基础治疗,试验组在对照组的治疗基础上增加皮下注射甲状旁腺激素20μg/d的辅助治疗。观察并比较2组手术前后髋关节疼痛程度、Harris功能评分和骨代谢指标等。结果2组术后髋关节痛感程度明显减轻,Harris评分及优良率提高,骨折愈合时间缩短,骨密度(BMD)、骨钙素(BGP)水平明显上升,碱性磷酸酶和β-CTX水平显著降低(P<0.05);与对照组相比,试验组改善均更明显(P<0.05)。结论甲状旁腺激素在辅助老年骨质疏松性股骨转子间骨折术后的愈合效果上作用明显,在降低病人术后痛感的同时能够促进骨折愈合和关节功能的恢复。
Objective To investigate the clinical efficacy of parathyroid hormone assisted in the elderly patients with osteoporotic fracture in the course of healing.Methods A total of 60 patients with osteoporotic fracture admitted to our hospital from January 2019 to December 2019 were prospectively selected and randomly divided into two groups,with 30 cases in each group.The control group was treated with conservative osteoporosis therapy,and the experimental group were treated with intermittent adjuvant subcutaneous injection of parathyroid hormone 20μg/d on the basis of the treatment of the control group.The recovery of fracture,bone metabolism index and pain degree and joint function were observed and compared.Results After the operation,the pain of joint was significantly alleviated,the excellent rate of hip Harris score was increased,the fracture healing time was shorter,the levels of bone mineral density(BMD)and bone gla protein(BGP)were increased,while the levels of alkaline phosphatase andβ-CrOSSlaps(β-CTX)were decreased significantly in two groups(P<0.05),especially in the experimental group(P<0.05).Conclusions Parathyroid hormone has a significant effect on postoperative healing of osteoporotic fracture,which can reduce postoperative pain and promote fracture healing and joint function recovery.
作者
宋耀东
姚刚
SONG Yao-dong;YAO Gang(Department of Orthopaedics,Anhui No.2 Provincial People's Hospital,Hefei 230041,China;Deartment of Orthopaedics,the First Affiliated Hospital of University of Science and Technology of China,Hefei 230036,China)
出处
《实用老年医学》
CAS
2021年第7期705-708,共4页
Practical Geriatrics
