摘要
目的探讨加味安神养血汤联合艾司唑仑治疗心脾两虚型亚健康失眠症患者的临床价值。方法选取2017年8月1日—2018年12月31日该院中医内科门诊60例顽固性失眠患者作为本次研究对象,按照随机数字表原则将其分为对照组和治疗组,均30例。对照组常规艾司唑仑干预,治疗组在此基础上口服安神养血汤综合调理,比较两组患者治疗30 d后临床总有效率,匹兹堡睡眠质量(PSQI)评分,睡眠质量及不良反应发生改善情况。结果治疗30 d后,治疗组总有效率为96.67%(29/30),对照组总有效率为73.33%(22/30),治疗组总有效率显著高于对照组(P<0.05),差异具统计学意义。治疗前,两组患者PQSI评分和睡眠质量比较无统计学意义(P>0.05);治疗30 d后,治疗组较对照组PQSI评分指数均明显降低,睡眠质量显著升高(P<0.05),差异具统计学意义。治疗组不良反应率为6.67%(2/30),对照组不良反应发生率为10.00%(3/30),治疗组不良反应发生率明显低于对照组(P<0.05),差异具统计学意义。结论加味安神养血汤联合艾司唑仑综合调理心脾两虚型亚健康失眠患者较单纯西药治疗具有显著临床疗效,不仅总体提升了患者睡眠质量,而且安全系数高,不良反应少,值得临床广泛应用和基层推广。
Objective To explore the clinical value of Jiawei Anshen Yangxue Decoction(加味安神养血汤) combined with estazolam in the treatment of sub-healthy insomnia patients with heart and spleen deficiency.Methods From August 1,2017 to December 31,2018,60 patients with refractory insomnia in our hospital were selected as the objects of this study,and they were divided into a control group and a treatment group according to the principle of random number table,each with 30 cases.The control group received routine estazolam intervention,and the treatment group took Anshen Yangxue Decoction for comprehensive conditioning.On this basis,the total clinical effectiveness,Pittsburgh sleep quality(PSQI) score,sleep quality and adverse reactions were compared after 30 days of treatment between the two groups.Results After 30 days of treatment,the total effective rate of the treatment group 96.67%(29/30),and that of the control group was 73.33%(22/30).The total effective rate of the treatment group was significantly higher than that of the control group(P<0.05).Before treatment,the PQSI score and sleep quality of the two groups were not statistically significant(P>0.05).After 30 days of treatment,the PQSI score of the treatment group was significantly lower than that of the control group,and the sleep quality was significantly increased(P<0.05).The incidence of adverse reactions in the treatment group was 6.67%(2/30) and the incidence of adverse reactions in the control group was 10.00%(3/30).The incidence of adverse reactions in the treatment group was significantly lower than that in the control group(P<0.05).Conclusion Jiawei Anshen Yangxue Decoction combined with estazolam for the comprehensive treatment of sub-healthy insomnia patients with heart and spleen deficiency has significant clinical efficacy than Western medicine alone.It not only improves the sleep quality of the patients in general,but also has a high safety factor and fewer adverse reactions.It is worthy of wide application and promotion.
作者
贾海波
王春葳
辛红
李建波
梁晓香
多慧玲
JIA Haibo;WANG Chunwei;XIN Hong;LI Jianbo;LIANG Xiaoxiang;DUO Huiling(Hebei People's Hospital Traditional Chinese Medicine,Shijiazhuang 050055,Hebei,China;The Fourth Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei,China;Laishui County Hospital of Baoding Pediatrics,Laishui 074100,Hebei,China;Shijiazhuang Xinhua LIANG Xiaoxiang Integrated Traditional Chinese and Western Medicine Clinic,Shijiazhuang 050000,Hebei,China;Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,Hebei,China)
出处
《辽宁中医杂志》
CAS
2021年第6期143-147,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
河北省中医药管理局科研计划项目(2017167)。
关键词
失眠
加味安神养血汤
心脾两虚
亚健康
PQSI
insomnia
Jiawei Anshen Yangxue Decoction(加味安神养血汤)
heart and spleen deficiency
sub-health
PQSI
