摘要
目的:探究microRNA-324-5p(miR-324-5p)在肝细胞癌(hepatocellular carcinoma,HCC)组织中的表达与病人预后危险因素。方法:通过TCGA(The Cancer Genome Atlas)数据库获得的肿瘤组织和正常肝组织miRNA表达谱数据与病人临床信息,分析miR-324-5p表达差异与病理的关系。通过绘制生存曲线分析miR-324-5p表达与病人预后的相关性。单因素和多因素Cox回归模型分析HCC相关危险因素。结果:miR-324-5p在HCC表达高于正常组织(P<0.001),且与不良预后相关。多因素Cox分析表明miR-324-5p可作为HCC预后不良的独立危险因素(P<0.05)。结论:miR-324-5p在HCC组织过表达,是HCC病人总生存期缩短的独立危险因素,为HCC预后判断的潜在生物学标志物。
Objective To study the expression of microRNA-324-5p(miR-324-5p)in hepatocellular carcinoma(HCC) and the prognosis risk factor in patients with HCC.Methods MiRNA expression database in tissue of both tumor and normal liver combined with clinical data of HCC patients were collected from The Cancer Genome Atlas(TCGA)database.Relationship between miR-324-5p expression and pathological features was analyzed.Relation of miR-324-5p expression to prognosis of the patients was analyzed through survival curve.Univariate and multivariate Cox regression models were used to analyze the risk factors related to HCC.Results The expressions of miR-324-5p in HCC were higher than those in normal tissues(P<0.001)and were associated with poor prognosis.Multivariate Cox analysis showed that miR-324-5p was an independent risk factor for HCC(P<0.05).Conclusions MiR-324-5p is upregulated in HCC,which play a role as risk factor in the HCC patients with shorten suvival and may be a possible biomarker of HCC prognosis prediction.
作者
吴城孝
方婕
周霁川
肖永胜
张晓光
WU Chengxiao;FANG Jie;ZHOU Jichuan;XIAO Yongsheng;ZHANG Xiaoguang(Department of Anesthesiology,Jinshan Hospital,Fudan University,Shanghai 201508,China;Department of Anesthesiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Liver Oncology Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
出处
《外科理论与实践》
2021年第3期249-253,共5页
Journal of Surgery Concepts & Practice
