摘要
目的探索丙戊酸钠联合齐拉西酮或奥氮平对双相Ⅰ型躁狂患者的认知水平、血清尿酸及血脂水平的影响。方法2017年2月~2019年2月期间我院收治的70例双相Ⅰ型躁狂患者,根据单双号随机分为两组,各35例,对照组采用丙戊酸钠联合奥氮平治疗,观察组采用丙戊酸钠联合齐拉西酮治疗,对比两组治疗后4周和8周的蒙特利尔认知量表(MoCA评分)、阳性和阴性症状量表评分(PANSS评分)、躁狂量表(BRMS)评分、血脂和尿酸水平。结果观察组治疗后4周、8周的BRMS评分、PANSS评分低于对照组(P<0.05),MoCA评分高于对照组(P<0.05),TC、TG、UA优于对照组(P<0.05)。结论丙戊酸钠联合齐拉西酮治疗双相Ⅰ型躁狂患者的效果显著,对尿酸、血脂水平影响更轻,可以改善患者的认知功能。
Objective To explore the effect of sodium valproate combined with ziprasidone or olanzapine on cognitive level,serum uric acid and blood lipid levels in manic episode patients with type I bipolar.Methods From February 2017 to February 2019,70 manic episode patients with type I bipolar were randomly divided into two group according to odd and even numbers,35 cases in each group.The control group was treated with sodium valproate combined with olanzapine The observation group was treated with sodium valproate combined with ziprasidone,and the Montreal Cognitive Scale(MoCA score),positive and negative symptom scale scores(PANSS score),Madness Scale(BRMS)score,blood lipids and uric acid beween two groups were compared after 4 and 8 weeks after treatment.Results After 4 weeks and 8 weeks of treatment,the BRMS score and PANSS score of the observation group were lower than those of the control group(P<0.05),the MoCA score was higher than that of the control group(P<0.05),and TC,TG and UA were better than the control group(P<0.05).Conclusion Sodium valproate combined with ziprasidone has a better effect on manic episode patients with type I bipolar,which can reduce manic symptoms,improve cognitive dysfunction,uric acid and blood lipid levels.
作者
王永良
魏冬
王敬巍
高志涛
WANG Yongliang;WEI Dong;WANG Jingwei(Department of Psychiatry,Luoyang Fifth People’s Hospital,Luoyang 471013,China)
出处
《国际精神病学杂志》
2021年第3期446-449,共4页
Journal Of International Psychiatry
关键词
丙戊酸钠
齐拉西酮
奥氮平
双相情感障碍
认知
尿酸
血脂
Sodium valproate
Ziprasidone
Olanzapine
Bipolar disorder
Cognition
Uric acid
Blood lipids
