摘要
通过动物和细胞实验,研究蒲公英水提物、醇提物对酒精性诱导的肝损伤相关指标(谷草转氨酶、谷丙转氨酶、甘油三酯、丙二醛、超氧化物歧化酶、谷胱甘肽)的影响规律;在此基础上,分析蒲公英水提物、醇提物的体内、体外抗氧化特性,探究蒲公英提取物保肝作用机制。结果表明,蒲公英水提物、醇提物均具有保护酒精性肝损伤的作用;与醇提物相比,水提物作用剂量更低,能有效降低血清中谷草转氨酶和肝脏中谷胱甘肽的含量,更好地保护肝细胞线粒体;抗氧化特性及相关性分析表明,蒲公英提取物的保肝效果与其抗氧化作用密切相关。
The effects of dandelion water extract and alcohol extract on alcohol-induced liver injury related indicators(glutamic oxaloacetic transaminase,glutamic pyruvic transaminase,triglyceride,malondialdehyde,superoxide dismutase,glutathione)were studied by animal and cell experiments.Then the antioxidant properties of water and alcohol extract of dandelion were determined in vitro and in vivo,and the liver-protecting mechanism of dandelion extract was explored.The results showed that both water extract and alcohol extract of dandelion had protective effect on alcoholic liver injury.Compared with alcohol extract,the water extract had lower action dose,and could effectively reduce the content of glutathione transaminase in serum and glutathione in liver,and better protect the mitochondria of hepatocytes.The antioxidant properties and correlation analysis showed that the liver protective effect of the dandelion extract was closely related to its antioxidant effect.
作者
夏金
陈义伦
XIA Jin;CHEN Yilun(College of Food Science and Engineering,Shandong Agricultural University,Taian 271018,China)
出处
《食品与发酵工业》
CAS
CSCD
北大核心
2021年第14期94-99,共6页
Food and Fermentation Industries
基金
山东省农业重大应用技术创新项目(2130106)。
关键词
蒲公英
提取物
酒精性肝损伤
抗氧化
保肝
dandelion
extract
alcoholic liver injury
antioxidant
protect liver
