摘要
It is reported that depression induced by frontal lobe injury(FLI)has a devastating effect on human mental health.We previously reported that fasciculation and elongation protein zeta-1(FEZ1)was essential for astrocytic protection of dopamine neurons.Studies of glutamate-glutamine cycle in mental ilness have been reported,whereas not from the perspective of astrocytes.This study was designed to investigate the role of astrocytic FEZ1 and glutamateglutamine cycle after FLI A model of FLI was established by inserting a blade into the right frontal lobe of rats.Behavioral test showed that FLI decreased exploratory activity.Western blot analysis revealed that the expression of astroglial proteins overall decreased in the initial injury stage,as well as FEZ1.
出处
《解剖学杂志》
CAS
2021年第S01期122-122,共1页
Chinese Journal of Anatomy
