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CRMP2 promotesthe trafficking of phosphorylated AMPA receptor GluA2 subunit

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摘要 CRMP2 is one of the well-studied members of the CRMPs family,which has been demonstrated not only play the roles in neurite extension,dendrites and dendritic spine development,but also in the AMPA receptor trafficking.However,the role of CRMP2 on the trafficking of AMPA receptor GluA2 subunit especially phosphorylated GluA2 is unknown.GST-Pull down and C-IP assays,immunofluorescence staining and whole cell patch clamp recording technique were performed in this study.The results showed that CRMP2 interacted with wild-type GluA2 and promoted the surface expression of wild-type GluA2.No matter GluA2 S880 was exogenously phosphorylated by phorbol myristate acetate(TPA)or endogenously phosphorylated by PKC5,CRMP2 can promote the surface expression of phosphorylated GluA2 and enhance its amplitude and frequency of mEPSCs,increasing the slope of the I-V curve.
出处 《解剖学杂志》 CAS 2021年第S01期80-80,共1页 Chinese Journal of Anatomy
关键词 CRMP2 ENDOGENOUS AMPA
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